Reactome | 2 Iron:FXN [mitochondrial matrix]

Schema > Complex > Entries

2 Iron:FXN [mitochondrial matrix] Show undefined attributes

catalystActivities	[CatalystActivity:9855646] iron chaperone activity of 2 Iron:FXN [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
componentOf	[Complex:R-HSA-1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9854405] Frataxin transfers Fe2+ to ACO2 - Homo sapiens
created	[InstanceEdit:1362403] May, B, 2011-06-09
dbId	1362402
displayName	2 Iron:FXN [mitochondrial matrix]
hasComponent	2 × [SimpleEntity:R-ALL-113531] Fe2+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-1362390] FXN(81-210) [mitochondrial matrix]
inDisease	false
inferredTo	[Complex:R-MMU-1362402] 2 Iron:FXN [mitochondrial matrix] - Mus musculus [Complex:R-RNO-1362402] 2 Iron:FXN [mitochondrial matrix] - Rattus norvegicus [Complex:R-CFA-1362402] 2 Iron:FXN [mitochondrial matrix] - Canis familiaris [Complex:R-BTA-1362402] 2 Iron:FXN [mitochondrial matrix] - Bos taurus [Complex:R-SSC-1362402] 2 Iron:FXN [mitochondrial matrix] - Sus scrofa [Complex:R-DRE-1362402] 2 Iron:FXN [mitochondrial matrix] - Danio rerio [Complex:R-XTR-1362402] 2 Iron:FXN [mitochondrial matrix] - Xenopus tropicalis [Complex:R-GGA-1362402] 2 Iron:FXN [mitochondrial matrix] - Gallus gallus [Complex:R-DME-1362402] 2 Iron:FXN [mitochondrial matrix] - Drosophila melanogaster [Complex:R-CEL-1362402] 2 Iron:FXN [mitochondrial matrix] - Caenorhabditis elegans [Complex:R-DDI-1362402] 2 Iron:FXN [mitochondrial matrix] - Dictyostelium discoideum [Complex:R-SPO-1362402] 2 Iron:FXN [mitochondrial matrix] - Schizosaccharomyces pombe [Complex:R-SCE-1362402] 2 Iron:FXN [mitochondrial matrix] - Saccharomyces cerevisiae [Complex:R-PFA-1362402] 2 Iron:FXN [mitochondrial matrix] - Plasmodium falciparum
isChimeric	false
literatureReference	[LiteratureReference:1362331] Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins [LiteratureReference:1362373] Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein [LiteratureReference:1362380] Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia
modified	[InstanceEdit:2466333] May, B, 2012-09-06
name	2 Iron:FXN
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1362402
summation	[Summation:1362310] Human Frataxin binds about 7 iron atoms (Yoon and Cowan 2003...

Referrals

(input)	[Reaction:R-HSA-9854405] Frataxin transfers Fe2+ to ACO2
(physicalEntity)	[CatalystActivity:9855646] iron chaperone activity of 2 Iron:FXN [mitochondrial matrix]
(hasComponent)	[Complex:R-HSA-1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]

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