Reactome | Engulfed CpG DNA binds to endosomal C-ter TLR9

Schema > Reaction > Entries

Engulfed CpG DNA binds to endosomal C-ter TLR9 Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	9997685
displayName	Engulfed CpG DNA binds to endosomal C-ter TLR9
eventOf	[Pathway:R-RNO-168138] Toll Like Receptor 9 (TLR9) Cascade - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Homo sapiens
input	[Complex:R-RNO-1679581] C-ter-TLR9 dimer [endosome membrane] [OtherEntity:R-ALL-167913] Unmethylated CpG DNA [endosome membrane]
isInDisease	false
isInferred	true
name	Engulfed CpG DNA binds to endosomal C-ter TLR9
output	[Complex:R-RNO-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane]
precedingEvent	[Reaction:R-RNO-1678920] TLR processing at low pH - Rattus norvegicus
regulatedBy	[PositiveRegulation:9997686] Positive regulation by 'EEA1:EEA1 [endosome membrane]' [NegativeRegulation:9997687] Negative regulation by 'C-ter TLR9 dimer:HCQ [endosome membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-187895
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-168138] Toll Like Receptor 9 (TLR9) Cascade
(precedingEvent)	[Reaction:R-RNO-188002] Rab5-mediated recruitment of class III PI3K to TLR9
(inferredTo)	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9