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Reaction
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Entries
CYP3A4 monooxygenates ATV to 4-OH-ATV
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authored
[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
catalystActivity
[CatalystActivity:9756317] monooxygenase activity of CYP3A4 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
dbId
9756162
displayName
CYP3A4 monooxygenates ATV to 4-OH-ATV
edited
[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
eventOf
[Pathway:R-HSA-9754706] Atorvastatin ADME - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Homo sapiens
input
[ChemicalDrug:R-ALL-9705596] ATV [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9756801] Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin
[LiteratureReference:9756790] Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors
modified
[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name
CYP3A4 monooxygenates ATV to 4-OH-ATV
orthologousEvent
[Reaction:R-GGA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Gallus gallus
[Reaction:R-XTR-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Xenopus tropicalis
[Reaction:R-DRE-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Danio rerio
[Reaction:R-SSC-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Sus scrofa
[Reaction:R-BTA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Bos taurus
[Reaction:R-CFA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Canis familiaris
[Reaction:R-RNO-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Rattus norvegicus
[Reaction:R-MMU-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Mus musculus
output
[ChemicalDrug:R-ALL-9756325] 4-OH-ATV [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Homo sapiens
releaseDate
2022-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9756162
summation
[Summation:9756792] Atorvastatin (ATV) is hydroxylated to hydroxy-metabolites, p...
Referrals
(hasEvent)
[Pathway:R-HSA-9754706] Atorvastatin ADME
(precedingEvent)
[BlackBoxEvent:R-HSA-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL
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