Reactome | UGT1A3 lactonizes ATV to ATVL

Schema > BlackBoxEvent > Entries

UGT1A3 lactonizes ATV to ATVL Show undefined attributes

authored	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
catalystActivity	[CatalystActivity:9756328] glucuronosyltransferase activity of UGT1A3 [endoplasmic reticulum membrane]
category	uncertain
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
dbId	9756156
displayName	UGT1A3 lactonizes ATV to ATVL
edited	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
eventOf	[Pathway:R-HSA-9754706] Atorvastatin ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9756138] CYP3A4 monooxygenates ATVL to 2-OH-ATVL - Homo sapiens [Reaction:R-HSA-9756177] PON1,3 hydrolyse ATVL to ATV - Homo sapiens [Reaction:R-HSA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Homo sapiens [Reaction:R-HSA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Homo sapiens
input	[ChemicalDrug:R-ALL-9705596] ATV [cytosol] [SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9756153] UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo [LiteratureReference:9756170] Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization [LiteratureReference:9756892] Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs)
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	UGT1A3 lactonizes ATV to ATVL
orthologousEvent	[BlackBoxEvent:R-DDI-9756156] UGT1A3 lactonizes ATV to ATVL - Dictyostelium discoideum [BlackBoxEvent:R-GGA-9756156] UGT1A3 lactonizes ATV to ATVL - Gallus gallus [BlackBoxEvent:R-SSC-9756156] UGT1A3 lactonizes ATV to ATVL - Sus scrofa [BlackBoxEvent:R-BTA-9756156] UGT1A3 lactonizes ATV to ATVL - Bos taurus [BlackBoxEvent:R-RNO-9756156] UGT1A3 lactonizes ATV to ATVL - Rattus norvegicus [BlackBoxEvent:R-MMU-9756156] UGT1A3 lactonizes ATV to ATVL - Mus musculus
output	[ChemicalDrug:R-ALL-9756319] ATVL [cytosol] [SimpleEntity:R-ALL-2162232] GlcA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent	[Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9756156
summation	[Summation:9756887] The acid form of atorvastatin (ATV) can be converted to its ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9756138] CYP3A4 monooxygenates ATVL to 2-OH-ATVL [Reaction:R-HSA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region [Reaction:R-HSA-9756177] PON1,3 hydrolyse ATVL to ATV [Reaction:R-HSA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL
(hasEvent)	[Pathway:R-HSA-9754706] Atorvastatin ADME