UniProt:A0A0C4DH25 IGKV3D-20

chain
  • signal peptide:1-20
  • chain:21-116
checksum 255BF9DEA53526CD
comment
  • FUNCTION V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGKV3D-20*01.CAUTION For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.
created [InstanceEdit:8944791] Weiser, JD
crossReference
databaseName UniProt
dbId 8944826
description
  • recommendedName: fullName evidence="3 8"Immunoglobulin kappa variable 3D-20
displayName UniProt:A0A0C4DH25 IGKV3D-20
geneName
  • IGKV3D-20
identifier A0A0C4DH25
isSequenceChanged false
keyword
  • Adaptive immunity
  • Cell membrane
  • Disulfide bond
  • Immunity
  • Immunoglobulin
  • Immunoglobulin domain
  • Membrane
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:11936968] Wright, Adam, 2024-03-11
name
  • IGKV3D-20
otherIdentifier
  • 11753832_x_at
  • 16882759
  • 211644_PM_x_at
  • 2492465
  • 2492468
  • 2493292
  • 2493294
  • 2493302
  • 2493305
  • 2493310
  • 2493312
  • 2493314
  • 2493316
  • 2493368
  • 2563836
  • 2563841
  • 2563862
  • 2563863
  • 2563885
  • 2563886
  • 2563905
  • 2563906
  • 2563907
  • 2563908
  • 2563909
  • 2563910
  • 2563912
  • 8043449
  • GO:0002250
  • GO:0002376
  • GO:0005576
  • GO:0005615
  • GO:0005886
  • GO:0006955
  • GO:0016020
  • GO:0019814
  • ILMN_1652199
  • TC02003401.hg
  • TC02004980.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KVD20_HUMAN
sequenceLength 116
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A0A0C4DH25
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