UniProt:O95405-1 ZFYVE9

chain
  • chain:1-1425
checksum ADE5CB530C1272C6
comment
  • FUNCTION Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.SUBUNIT Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML.INTERACTION Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.DOMAIN The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3.DOMAIN The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 58931
description
  • recommendedName: Zinc finger FYVE domain-containing protein 9 alternativeName: Mothers against decapentaplegic homolog-interacting protein shortName: Madh-interacting protein alternativeName: Novel serine protease shortName: NSP alternativeName: Receptor activation anchor shortName: hSARA alternativeName: Smad anchor for receptor activation
displayName UniProt:O95405-1 ZFYVE9
geneName
  • ZFYVE9
  • MADHIP
  • SARA
  • SMADIP
identifier O95405
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Endosome
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ZFYVE9
otherIdentifier
  • 11730983_a_at
  • 11730984_a_at
  • 11738130_a_at
  • 16664708
  • 204893_PM_s_at
  • 204893_s_at
  • 208446_PM_s_at
  • 208446_s_at
  • 2336305
  • 2336306
  • 2336307
  • 2336308
  • 2336321
  • 2336322
  • 2336323
  • 2336324
  • 2336325
  • 2336326
  • 2336327
  • 2336328
  • 2336335
  • 2336339
  • 2336341
  • 2336342
  • 2336343
  • 2336344
  • 2336347
  • 2336350
  • 2336354
  • 2336356
  • 2336357
  • 2336360
  • 2336361
  • 2336363
  • 2336364
  • 2336365
  • 2336366
  • 2336368
  • 3615376
  • 38889_at
  • 3992804
  • 3992805
  • 3992808
  • 3992810
  • 7901426
  • 9372
  • A_14_P101368
  • A_23_P33768
  • GE62107
  • GO:0005515
  • GO:0005545
  • GO:0005737
  • GO:0005768
  • GO:0005769
  • GO:0005829
  • GO:0006897
  • GO:0007179
  • GO:0008289
  • GO:0016020
  • GO:0016192
  • GO:0016197
  • GO:0019904
  • GO:0023052
  • GO:0031410
  • GO:0031901
  • GO:0032991
  • GO:0043226
  • GO:0043231
  • GO:0046872
  • HMNXSV003026189
  • ILMN_1776848
  • ILMN_1799622
  • ILMN_2381994
  • PH_hs_0027270
  • TC01000639.hg
  • g4759059_3p_a_at
  • g6552336_3p_a_at
  • g6552336_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • ZFYV9_HUMAN
  • Q5T0F6
  • Q5T0F7
  • Q9UNE1
  • Q9Y5R7
sequenceLength 1425
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O95405-1
variantIdentifier O95405-1
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