UniProt:O75521-2 ECI2

chain
  • transit peptide:1-38
  • chain:39-394
checksum 8AC633D43A320102
comment
  • FUNCTION Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.CATALYTIC ACTIVITY a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (3Z)-octenoyl-CoA = (2E)-octenoyl-CoACATALYTIC ACTIVITY a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoACATALYTIC ACTIVITY (3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoACATALYTIC ACTIVITY (3E)-octenoyl-CoA = (2E)-octenoyl-CoACATALYTIC ACTIVITY (3E)-nonenoyl-CoA = (2E)-nonenoyl-CoAPATHWAY Lipid metabolism; fatty acid beta-oxidation.INTERACTION Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.SIMILARITY In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.CAUTION It is uncertain whether Met-1 or Met-3 is the initiator.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:435871] Kanapin, AA
crossReference
databaseName UniProt
dbId 436229
description
  • recommendedName: fullName evidence="15"Enoyl-CoA delta isomerase 2 ecNumber evidence="8"5.3.3.8 alternativeName: DRS-1 alternativeName: Delta(3),delta(2)-enoyl-CoA isomerase shortName: D3,D2-enoyl-CoA isomerase alternativeName: Diazepam-binding inhibitor-related protein 1 shortName: DBI-related protein 1 alternativeName: Dodecenoyl-CoA isomerase alternativeName: Hepatocellular carcinoma-associated antigen 88 alternativeName: Peroxisomal 3,2-trans-enoyl-CoA isomerase shortName evidence="12"pECI alternativeName: Renal carcinoma antigen NY-REN-1
displayName UniProt:O75521-2 ECI2
geneName
  • ECI2
  • DRS1
  • HCA88
  • PECI
identifier O75521
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Isomerase
  • Mitochondrion
  • Peroxisome
  • Phosphoprotein
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ECI2
otherIdentifier
  • 10455
  • 11754652_a_at
  • 17015240
  • 218025_PM_s_at
  • 218025_s_at
  • 2939594
  • 2939595
  • 2939596
  • 2939598
  • 2939599
  • 2939601
  • 2939603
  • 2939606
  • 2939607
  • 2939609
  • 2939610
  • 2939611
  • 2939616
  • 44706_at
  • 8123695
  • A_23_P156852
  • GO:0000062
  • GO:0003824
  • GO:0004165
  • GO:0005515
  • GO:0005739
  • GO:0005777
  • GO:0005782
  • GO:0005829
  • GO:0006629
  • GO:0006635
  • GO:0008289
  • GO:0016020
  • GO:0016853
  • GO:0043226
  • GO:0043231
  • HMNXSV003031559
  • ILMN_1761131
  • ILMN_2384536
  • PH_hs_0001423
  • TC06003424.hg
  • g5174624_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • ECI2_HUMAN
  • Q5JYK5
  • Q5JYK7
  • Q7L124
  • Q8N0X0
  • Q9BUE9
  • Q9H0T9
  • Q9NQH1
  • Q9NYH7
  • Q9UN55
sequenceLength 394
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O75521-2
variantIdentifier O75521-2
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