Reactome | UniProt:A6H8Y1 BDP1

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UniProt:A6H8Y1 BDP1 Show undefined attributes

chain	chain:1-2624
checksum	CB7B80EBBF06B557
comment	FUNCTION General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.SUBUNIT Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43.SUBCELLULAR LOCATION Isoform 2 is highly expressed in cerebellum.INDUCTION By Epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes.PTM Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference	[DatabaseIdentifier:10973743] Pharos - Targets:A6H8Y1 [DatabaseIdentifier:11059517] OpenTargets:ENSG00000145734 [DatabaseIdentifier:11610622] RefSeq:NP_060899.2 [DatabaseIdentifier:11742149] PDB:5N9G [DatabaseIdentifier:11742157] PDB:8ITY [DatabaseIdentifier:11742161] PDB:8IUE [DatabaseIdentifier:11742169] PDB:8IUH [DatabaseIdentifier:11814822] PRO:A6H8Y1 [DatabaseIdentifier:11846275] GeneCards:A6H8Y1 [DatabaseIdentifier:11882554] Orphanet:24364 [DatabaseIdentifier:11895814] HPA:ENSG00000145734-BDP1 [DatabaseIdentifier:12050272] Ensembl:ENSP00000351575 [DatabaseIdentifier:12050273] Ensembl:ENSG00000145734 [DatabaseIdentifier:12050274] Ensembl:ENST00000358731 [DatabaseIdentifier:12050275] Ensembl:ENST00000617085 [DatabaseIdentifier:12050276] Ensembl:ENSP00000482469 [DatabaseIdentifier:12050277] Ensembl:ENSG00000273873
databaseName	UniProt
dbId	354544
description	recommendedName: Transcription factor TFIIIB component B'' homolog alternativeName: Transcription factor IIIB 150 shortName: TFIIIB150 alternativeName: Transcription factor-like nuclear regulator
displayName	UniProt:A6H8Y1 BDP1
geneName	BDP1 KIAA1241 KIAA1689 TFNR
identifier	A6H8Y1
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Coiled coil Deafness Non-syndromic deafness Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	BDP1
otherIdentifier	11721969_s_at 11721970_a_at 11745668_a_at 16985852 224227_PM_s_at 224227_s_at 226290_PM_at 226290_at 231939_PM_s_at 231939_s_at 2814545 2814546 2814547 2814548 2814549 2814550 2814551 2814552 2814553 2814554 2814555 2814556 2814557 2814559 2814562 2814563 2814565 2814567 2814568 2814569 2814570 2814571 2814572 2814574 2814575 2814578 2814581 2814582 2814583 2814585 2814588 2814589 2814590 2814591 2814592 2814593 2814595 2814598 2814599 2814601 2814602 2814605 2814606 2814608 2814611 2814612 2814613 2814614 2814615 2814619 2814620 2814621 3814212 55814 64887_at 8106025 8177560 A_23_P7483 A_24_P26342 A_24_P42316 A_24_P940776 GE62708 GO:0000126 GO:0001156 GO:0005515 GO:0005634 GO:0005654 GO:0006351 GO:0043226 GO:0065003 GO:0070898 HMNXSV003005120 HMNXSV003040977 Hs.272808.1.A1_3p_at Hs.272808.2.A1_3p_a_at ILMN_1687149 PH_hs_0014092 TC05000333.hg g11096172_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-83687] BDP1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8989982] ENSEMBL:ENSG00000145734 BDP1 [ReferenceDNASequence:11029060] KEGG Gene (Homo sapiens):55814 BDP1 [ReferenceDNASequence:11263734] NCBI Gene:55814 BDP1 [ReferenceDNASequence:11263735] BioGPS Gene:55814 BDP1 [ReferenceDNASequence:11263736] CTD Gene:55814 BDP1 [ReferenceDNASequence:11263737] dbSNP Gene:55814 BDP1 [ReferenceDNASequence:11263738] Monarch:55814 BDP1 [ReferenceDNASequence:11345297] ENSEMBL_homo_sapiens_GENE:ENSG00000145734.20 BDP1 [ReferenceDNASequence:11345311] ENSEMBL_homo_sapiens_GENE:ENSG00000273873.4 BDP1 [ReferenceDNASequence:11517116] UCSC:A6H8Y1 BDP1 [ReferenceDNASequence:11800516] OMIM:607012 BDP1 [ReferenceDNASequence:11873628] HGNC:13652 BDP1 [ReferenceDNASequence:12194299] COSMIC (genes):BDP1 BDP1
referenceTranscript	[ReferenceRNASequence:11442909] RefSeq:NM_018429.2 BDP1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BDP1_HUMAN Q68DS6 Q68DY5 Q6MZL9 Q6PIM7 Q86W98 Q96LR8 Q9C0H4 Q9H197 Q9H1A1 Q9HAW1 Q9HAW2 Q9HCY0 Q9ULH9
sequenceLength	2624
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/A6H8Y1

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-83687] BDP1 [nucleoplasm]