Reactome | gain_of_function via inframe

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gain_of_function via inframe_deletion Show undefined attributes

created	[InstanceEdit:2632524] Orlic-Milacic, M, 2012-11-21
dbId	2632527
displayName	gain_of_function via inframe_deletion
functionalStatusType	[FunctionalStatusType:2426108] gain_of_function
schemaClass	FunctionalStatus
structuralVariant	[SequenceOntology:2318498] inframe_deletion

Referrals

(functionalStatus)

[EntityFunctionalStatus:9630131] gain_of_function of ub-CFTR F508del [cytosol]
[EntityFunctionalStatus:9630127] gain_of_function of CFTR F508del [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9630129] gain_of_function of CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9630134] gain_of_function of ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9037676] gain_of_function of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:9630163] gain_of_function of p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane]
[EntityFunctionalStatus:9630165] gain_of_function of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9630101] gain_of_function of p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
[EntityFunctionalStatus:9037674] gain_of_function of p-5Y-EGFRvIII:SHC1 [plasma membrane]
[EntityFunctionalStatus:9630158] gain_of_function of p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane]
[EntityFunctionalStatus:9630169] gain_of_function of p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5637727] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
[EntityFunctionalStatus:5637720] gain_of_function of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5637724] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]
[EntityFunctionalStatus:5637731] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
[EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
[EntityFunctionalStatus:5637719] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
[EntityFunctionalStatus:5637730] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5637725] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:5637722] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:9630152] gain_of_function of EGFRvIII [plasma membrane]
[EntityFunctionalStatus:9630155] gain_of_function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:6802906] gain_of_function of V600E BRAF splice variants [cytosol]
[EntityFunctionalStatus:9652162] gain_of_function of MAP2K1 and MAP2K2 mutants [cytosol]
[EntityFunctionalStatus:9670388] gain_of_function of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
[EntityFunctionalStatus:9670386] gain_of_function of KIT mutant dimers:SFKs [plasma membrane]
[EntityFunctionalStatus:9670402] gain_of_function of p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]
[EntityFunctionalStatus:9669908] gain_of_function of juxtamembrane domain KIT mutant dimers [plasma membrane]
[EntityFunctionalStatus:9669905] gain_of_function of juxtamembrane domain KIT mutants [plasma membrane]
[EntityFunctionalStatus:9670395] gain_of_function of PI3K:p-KIT mutant dimers [plasma membrane]
[EntityFunctionalStatus:9670398] gain_of_function of p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane]
[EntityFunctionalStatus:9670393] gain_of_function of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
[EntityFunctionalStatus:9670390] gain_of_function of KIT mutant dimers:SFKs:p-JAK2 [plasma membrane]
[EntityFunctionalStatus:9670400] gain_of_function of p-KIT mutants:GRB2:SOS [plasma membrane]
[EntityFunctionalStatus:9670397] gain_of_function of p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane]
[EntityFunctionalStatus:9680254] gain_of_function of extracellular domain mutants of KIT [plasma membrane]
[EntityFunctionalStatus:9680251] gain_of_function of extracellular domain mutant dimers of KIT [plasma membrane]
[EntityFunctionalStatus:9695835] gain_of_function of FLT3 extracellular domain, kinase domain and juxtamembrane domain mutants [plasma membrane]
[EntityFunctionalStatus:9665011] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9664998] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9664607] gain_of_function of Heterodimers of ERBB2 KD mutants [plasma membrane]
[EntityFunctionalStatus:9664569] gain_of_function of ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9664971] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane]
[EntityFunctionalStatus:9664951] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane]
[EntityFunctionalStatus:9664980] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane]
[EntityFunctionalStatus:9664989] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:2632525] gain_of_function of PI3K mutants [plasma membrane]
[EntityFunctionalStatus:9672144] gain_of_function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]
[EntityFunctionalStatus:9672150] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672147] gain_of_function of PDGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane]
[EntityFunctionalStatus:9672151] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672149] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672146] gain_of_function of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9672153] gain_of_function of p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672148] gain_of_function of p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672156] gain_of_function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9673665] gain_of_function of PDGFRA extracellular domain mutants [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672152] gain_of_function of p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672145] gain_of_function of p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672154] gain_of_function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9674446] gain_of_function of type I TKI sensitive PDGFR mutants [plasma membrane]
[EntityFunctionalStatus:9674448] gain_of_function of type II TKI sensitive PDGFR mutants [plasma membrane]
[EntityFunctionalStatus:5637718] gain_of_function of Ligand-responsive EGFR mutants [plasma membrane]
[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:5637732] gain_of_function of Active dimers of ligand-responsive EGFR mutants [plasma membrane]
[EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:5637729] gain_of_function of EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:5638088] gain_of_function of EGFRvIII mutant dimer [plasma membrane]

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