Reactome | UniProt:A0MZ66 SHTN1

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UniProt:A0MZ66 SHTN1 Show undefined attributes

chain	chain:1-631
checksum	826B88F18151228D
comment	FUNCTION Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.SUBUNIT Interacts with L1CAM; this interaction occurs in axonal growth cones. Interacts with actin filament retrograde flow; this interaction is enhanced in a netrin-1- and PAK1-dependent manner and promotes F-actin-substrate coupling and concomitant formation of traction forces at axonal growth cones. Interacts with RUFY3. Interacts with PFN2. Interacts (via N-terminus) with KIF20B; this interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons. Associates with microtubule.INTERACTION Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones. Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons. Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner.ALTERNATIVE PRODUCTS The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones.PTM Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones. Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1.SIMILARITY Belongs to the shootin family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:10979399] Pharos - Targets:A0MZ66 [DatabaseIdentifier:11076356] OpenTargets:ENSG00000187164 [DatabaseIdentifier:11621960] RefSeq:NP_001120683.1 [DatabaseIdentifier:11621974] RefSeq:NP_001245227.1 [DatabaseIdentifier:11621991] RefSeq:NP_001245228.1 [DatabaseIdentifier:11622002] RefSeq:NP_001245229.1 [DatabaseIdentifier:11622013] RefSeq:NP_060800.2 [DatabaseIdentifier:11622024] RefSeq:XP_016871951.1 [DatabaseIdentifier:11838627] PRO:A0MZ66 [DatabaseIdentifier:11848342] GeneCards:A0MZ66 [DatabaseIdentifier:11889154] HMDB Protein:HMDBP14122 [DatabaseIdentifier:11901539] HPA:ENSG00000187164-SHTN1 [DatabaseIdentifier:12095080] Ensembl:ENSG00000187164 [DatabaseIdentifier:12095081] Ensembl:ENSP00000260777 [DatabaseIdentifier:12095082] Ensembl:ENSP00000480109 [DatabaseIdentifier:12095083] Ensembl:ENST00000355371 [DatabaseIdentifier:12095084] Ensembl:ENST00000392901 [DatabaseIdentifier:12095085] Ensembl:ENSP00000347532 [DatabaseIdentifier:12095086] Ensembl:ENST00000392903 [DatabaseIdentifier:12095087] Ensembl:ENST00000260777 [DatabaseIdentifier:12095088] Ensembl:ENST00000615301 [DatabaseIdentifier:12095089] Ensembl:ENSP00000376635 [DatabaseIdentifier:12095090] Ensembl:ENSP00000376636
databaseName	UniProt
dbId	248278
description	recommendedName: fullName evidence="11"Shootin-1 alternativeName: fullName evidence="1"Shootin1
displayName	UniProt:A0MZ66 SHTN1
geneName	SHTN1 KIAA1598
identifier	A0MZ66
isSequenceChanged	false
keyword	Acetylation Alternative splicing Cell projection Coiled coil Cytoplasm Cytoskeleton Developmental protein Direct protein sequencing Phosphoprotein Reference proteome
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	SHTN1
otherIdentifier	11735039_s_at 11749674_a_at 11750307_a_at 16718719 221802_PM_s_at 221802_s_at 3308484 3308486 3308488 3308490 3308491 3308492 3308493 3308512 3308513 3308514 3308516 3308517 3308521 3308522 3308524 3308525 3308526 3308528 3308529 3308531 3308532 3308533 3308535 3308537 3308539 3308541 3308546 3308549 3308550 3308551 3308552 3308553 3308554 3308555 3308556 44072_at 57698 61403_at 78441_at 7936529 A_23_P202587 A_32_P79178 A_33_P3382236 A_33_P3419139 GE56835 GO:0005515 GO:0005737 GO:0005856 GO:0005874 GO:0005875 GO:0006930 GO:0007010 GO:0007163 GO:0007265 GO:0007409 GO:0008092 GO:0015630 GO:0019894 GO:0023052 GO:0030027 GO:0030154 GO:0030175 GO:0030424 GO:0030426 GO:0031252 GO:0032488 GO:0038007 GO:0042802 GO:0042995 GO:0043204 GO:0043226 GO:0044295 GO:0045296 GO:0045773 GO:0048471 GO:0048812 GO:0048856 GO:0048870 GO:0051015 GO:0060327 GO:0061163 GO:0061573 GO:2000114 GO:2001222 GO:2001224 HMNXSV003020118 HMNXSV003055774 Hs.23740.1.S1_3p_a_at ILMN_1805992 PH_hs_0022231 PH_hs_0040972 TC10001683.hg p33752
physicalEntity	[EntityWithAccessionedSequence:R-HSA-443599] KIAA1598 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8989814] ENSEMBL:ENSG00000187164 SHTN1 [ReferenceDNASequence:11030365] KEGG Gene (Homo sapiens):57698 SHTN1 [ReferenceDNASequence:11278155] NCBI Gene:57698 SHTN1 [ReferenceDNASequence:11278156] BioGPS Gene:57698 SHTN1 [ReferenceDNASequence:11278157] CTD Gene:57698 SHTN1 [ReferenceDNASequence:11278158] dbSNP Gene:57698 SHTN1 [ReferenceDNASequence:11278159] Monarch:57698 SHTN1 [ReferenceDNASequence:11351679] ENSEMBL_homo_sapiens_GENE:ENSG00000187164.20 SHTN1 [ReferenceDNASequence:11517553] UCSC:A0MZ66 SHTN1 [ReferenceDNASequence:11802016] OMIM:611171 SHTN1 [ReferenceDNASequence:11875699] HGNC:29319 SHTN1 [ReferenceDNASequence:12191781] COSMIC (genes):SHTN1 SHTN1
referenceTranscript	[ReferenceRNASequence:11453336] RefSeq:NM_001127211.2 SHTN1 [ReferenceRNASequence:11453342] RefSeq:NM_001258298.1 SHTN1 [ReferenceRNASequence:11453349] RefSeq:NM_001258299.1 SHTN1 [ReferenceRNASequence:11453355] RefSeq:NM_001258300.1 SHTN1 [ReferenceRNASequence:11453363] RefSeq:NM_018330.6 SHTN1 [ReferenceRNASequence:11453368] RefSeq:XM_017016462.1 SHTN1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SHOT1_HUMAN A8MYU7 B3KRD3 B3KRH2 B3KTE0 B3KTJ7 B3KTJ8 B4E3U1 B7Z7Z9 Q68DG1 Q6PIM5 Q9HCH4 Q9NUV0
sequenceLength	631
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/A0MZ66

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-443599] KIAA1598 [cytosol]
(interactor)	[UndirectedInteraction:12205039] UniProt:A0MZ66 <-> UniProt:Q9Y5B8 (IntAct) [UndirectedInteraction:12205029] UniProt:A0MZ66 <-> UniProt:P61981 (IntAct) [UndirectedInteraction:12205031] UniProt:A0MZ66 <-> UniProt:P62508 (IntAct) [UndirectedInteraction:12205033] UniProt:A0MZ66 <-> UniProt:P05413 (IntAct) [UndirectedInteraction:12205037] UniProt:A0MZ66 <-> UniProt:Q6PJR7 (IntAct)