UniProt:A5LHX3 PSMB11

chain
  • propeptide:1-49
  • chain:50-300
checksum 234ECBD1D230A7E8
comment
  • FUNCTION The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).CATALYTIC ACTIVITY Cleavage of peptide bonds with very broad specificity.SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8.INTERACTION Belongs to the peptidase T1B family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 244089
description
  • recommendedName: Proteasome subunit beta type-11 ecNumber: 3.4.25.1 alternativeName: Proteasome subunit beta-5t
displayName UniProt:A5LHX3 PSMB11
geneName
  • PSMB11
identifier A5LHX3
isSequenceChanged false
keyword
  • Cytoplasm
  • Hydrolase
  • Nucleus
  • Protease
  • Proteasome
  • Reference proteome
  • Threonine protease
  • Zymogen
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • PSMB11
otherIdentifier
  • 11740519_at
  • 122706
  • 16782247
  • 3528980
  • 3528981
  • 3528982
  • 3528983
  • 3528984
  • 3528985
  • 3528986
  • 3528987
  • 7973369
  • A_33_P3229375
  • A_33_P3250895
  • GO:0000502
  • GO:0002376
  • GO:0003824
  • GO:0004175
  • GO:0004298
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005839
  • GO:0006508
  • GO:0008233
  • GO:0010498
  • GO:0016787
  • GO:0019774
  • GO:0030154
  • GO:0030163
  • GO:0033077
  • GO:0043226
  • GO:0043374
  • GO:0048856
  • GO:0051603
  • GO:0140096
  • HMNXSV003028656
  • ILMN_1797406
  • PH_hs_0034216
  • TC14000140.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSB11_HUMAN
sequenceLength 300
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A5LHX3
Cite Us!