UniProt:O75469-7 NR1I2

chain
  • chain:1-434
checksum 1DF6A2AE3109C4DA
comment
  • FUNCTION Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.SUBUNIT Heterodimer with RXR. Interacts with NCOA1. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).INTERACTION Expressed in liver, colon and small intestine.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 240050
description
  • recommendedName: Nuclear receptor subfamily 1 group I member 2 alternativeName: Orphan nuclear receptor PAR1 alternativeName: Orphan nuclear receptor PXR alternativeName: Pregnane X receptor alternativeName: Steroid and xenobiotic receptor shortName: SXR
displayName UniProt:O75469-7 NR1I2
geneName
  • NR1I2
  • PXR
identifier O75469
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • DNA-binding
  • Metal-binding
  • Nucleus
  • Receptor
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • NR1I2
otherIdentifier
  • 11738805_a_at
  • 11740333_a_at
  • 16944464
  • 207202_PM_s_at
  • 207202_s_at
  • 207203_PM_s_at
  • 207203_s_at
  • 2638176
  • 2638178
  • 2638179
  • 2638180
  • 2638181
  • 2638182
  • 2638183
  • 2638184
  • 2638185
  • 2638186
  • 2638190
  • 2638191
  • 2638192
  • 2638198
  • 2638201
  • 2638202
  • 2638203
  • 2638206
  • 2638208
  • 2638209
  • 2638212
  • 2638213
  • 2638214
  • 2638215
  • 35114_at
  • 8081925
  • 8856
  • A_14_P132184
  • A_23_P109785
  • GE55185
  • GO:0000122
  • GO:0000785
  • GO:0000977
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0003677
  • GO:0003700
  • GO:0004879
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005667
  • GO:0005694
  • GO:0005856
  • GO:0006351
  • GO:0006355
  • GO:0006629
  • GO:0006805
  • GO:0007165
  • GO:0008202
  • GO:0008270
  • GO:0010628
  • GO:0016604
  • GO:0016922
  • GO:0023052
  • GO:0030154
  • GO:0030522
  • GO:0042178
  • GO:0042908
  • GO:0043226
  • GO:0043565
  • GO:0045111
  • GO:0045892
  • GO:0045893
  • GO:0045944
  • GO:0046872
  • GO:0060089
  • GO:0140110
  • GO:1990837
  • HMNXSV003033700
  • ILMN_1806561
  • ILMN_2240109
  • ILMN_2323338
  • PH_hs_0006489
  • TC03000613.hg
  • g11863133_3p_a_at
  • g3511137_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • NR1I2_HUMAN
  • Q006P5
  • Q008C8
  • Q96AC7
  • Q9UJ22
  • Q9UJ23
  • Q9UJ24
  • Q9UJ25
  • Q9UJ26
  • Q9UJ27
  • Q9UNW4
sequenceLength 434
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O75469-7
variantIdentifier O75469-7
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