Reactome | acute lymphocytic leukemia

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acute lymphocytic leukemia Show undefined attributes

created	[InstanceEdit:2317483] Orlic-Milacic, M, 2012-06-11
databaseName	DOID
dbId	2317476
displayName	acute lymphocytic leukemia
identifier	9952
name	acute lymphocytic leukemia
referenceDatabase	[ReferenceDatabase:1247631] DOID
schemaClass	Disease
url	https://www.ebi.ac.uk/ols/ontologies/doid/terms?obo_id=DOID:9952

Referrals

(disease)

[ChemicalDrug:R-ALL-9759446] PREDN (kidney cell) [cytosol]
[ChemicalDrug:R-ALL-9759404] PREDN (hepatocyte) [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632585] p16INK4A W110* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632586] p16INK4A R80* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632582] p16INK4A R58* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632587] p16INK4A E120* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9631306] p16INK4A G35A [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688140] RB1 M148Hfs*9 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688110] RB1 E209Vfs*3 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688078] RB1 D856Efs*17 [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500701] PIK3CA E542K [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500705] PIK3CA Q546K [cytosol]
[EntityWithAccessionedSequence:R-HSA-2317478] PTEN R173C [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659052] PTEN E99* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659318] PTEN Q97* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659113] PTEN G293* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659195] PTEN L247* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659124] PTEN G209* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659314] PTEN Q298* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659393] PTEN W274* [cytosol]
[EntityWithAccessionedSequence:R-HSA-2318573] PTEN R233* [cytosol]
[EntityWithAccessionedSequence:R-HSA-2318568] PTEN R335* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659158] PTEN K221* [cytosol]
[Complex:R-HSA-9691981] FLT3 K663Q dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9691908] FLT3 K663Q [plasma membrane]
[Complex:R-HSA-9695763] FLT3 D839G dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9695718] FLT3 D839G [plasma membrane]
[Complex:R-HSA-9691965] FLT3 K633R dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9691898] FLT3 K633R [plasma membrane]
[Complex:R-HSA-9695789] p-6Y FLT3 D839G dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9695737] p-6Y FLT3 D839G [plasma membrane]
[Complex:R-HSA-9691995] p-6Y FLT3 K663Q dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9691942] p-6Y FLT3 K663Q [plasma membrane]
[Complex:R-HSA-9691990] p-6Y FLT3 K633R dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9691940] p-6Y FLT3 K633R [plasma membrane]
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
[Reaction:R-HSA-1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
[Reaction:R-HSA-1839112] Phosphorylation of STAT5 by cytosolic FGFR1 fusions
[Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation
[Complex:R-HSA-1839036] FGFR1 fusion mutant dimers:TKIs [cytosol]
[CandidateSet:R-HSA-1839029] cytosolic FGFR1 fusion mutants [cytosol]
[ChemicalDrug:R-ALL-9692412] navitoclax [cytosol]
[EntityWithAccessionedSequence:R-HSA-9647542] NF1 R1534* [cytosol]
[ChemicalDrug:R-ALL-9660765] PREDN [cytosol]
[ChemicalDrug:R-ALL-9660782] PREDN [extracellular region]
[EntityWithAccessionedSequence:R-HSA-1838987] CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1838989] CPSF6-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1839002] LRRFIP1(1-249)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839005] LRRFIP1-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1839006] MYO18A(1-1691)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839009] MYO18A-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1838982] CNTRL(1-808)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1838984] CNTRL-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1838998] FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839001] FGFR1OP2-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1839016] ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839019] ZMYM2-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1838979] BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1838980] BCR-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1838994] FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1838997] FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1839012] TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839015] TRIM24-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1838991] CUX1(1-339)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1838992] CUX1-p-FGFR1 fusion mutant dimer [cytosol]
[CandidateSet:R-HSA-1839020] cytosolic p-FGFR1 fusion mutant dimers [cytosol]
[EntityWithAccessionedSequence:R-HSA-1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1604537] LRRFIP1(1-249)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1604541] LRRFIP1-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1606446] MYO18A(1-1691)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1637934] MYO18A-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1614368] CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1637878] CPSF6-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1614371] CUX1(1-339)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1637880] CUX1-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1606443] FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1637884] FGFR1OP2-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1604524] BCR(1-584)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1604525] BCR-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1604544] ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1604545] ZMYM2-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1614442] TRIM24(1-626)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1638017] TRIM24-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1604528] CNTRL(1-808)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1604531] CNTRL-FGFR1 fusion mutant dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-1604533] FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol]
[Complex:R-HSA-1604535] FGFR1OP-FGFR1 fusion mutant dimer [cytosol]
[CandidateSet:R-HSA-1839026] cytosolic FGFR1 fusion mutant dimers [cytosol]

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