Reactome | UniProt:P00390-2 GSR

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UniProt:P00390-2 GSR Show undefined attributes

chain	transit peptide:1-43 chain:44-522
checksum	DD8E2BA9D6E3757B
comment	FUNCTION Maintains high levels of reduced glutathione in the cytosol.CATALYTIC ACTIVITY 2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPHCOFACTOR Binds 1 FAD per subunit.SUBUNIT Homodimer; disulfide-linked.SUBCELLULAR LOCATION Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The active site is a redox-active disulfide bond.MISCELLANEOUS Produced by alternative initiation of isoform Mitochondrial.MISCELLANEOUS Expressed at very high levels in peripheral blood.SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.SEQUENCE CAUTION Glutathione reductase entry
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:10970077] Pharos - Targets:P00390 [DatabaseIdentifier:10981971] Guide to Pharmacology - Targets:2613 [DatabaseIdentifier:11044686] IntEnz:1.8.1.7 [DatabaseIdentifier:11049641] OpenTargets:ENSG00000104687 [DatabaseIdentifier:11604380] RefSeq:NP_000628.2 [DatabaseIdentifier:11604395] RefSeq:NP_001182031.1 [DatabaseIdentifier:11604420] RefSeq:NP_001182032.1 [DatabaseIdentifier:11604433] RefSeq:NP_001182033.1 [DatabaseIdentifier:11723032] PDB:1ALG [DatabaseIdentifier:11723051] PDB:1BWC [DatabaseIdentifier:11723077] PDB:1DNC [DatabaseIdentifier:11723093] PDB:1GRA [DatabaseIdentifier:11723112] PDB:1GRB [DatabaseIdentifier:11723137] PDB:1GRE [DatabaseIdentifier:11723166] PDB:1GRF [DatabaseIdentifier:11723181] PDB:1GRG [DatabaseIdentifier:11723201] PDB:1GRH [DatabaseIdentifier:11723216] PDB:1GRT [DatabaseIdentifier:11723222] PDB:1GSN [DatabaseIdentifier:11723247] PDB:1K4Q [DatabaseIdentifier:11723253] PDB:1XAN [DatabaseIdentifier:11723256] PDB:2AAQ [DatabaseIdentifier:11723271] PDB:2GH5 [DatabaseIdentifier:11723291] PDB:2GRT [DatabaseIdentifier:11723321] PDB:3DJG [DatabaseIdentifier:11723338] PDB:3DJJ [DatabaseIdentifier:11723361] PDB:3DK4 [DatabaseIdentifier:11723383] PDB:3DK8 [DatabaseIdentifier:11723408] PDB:3DK9 [DatabaseIdentifier:11723438] PDB:3GRS [DatabaseIdentifier:11723457] PDB:3GRT [DatabaseIdentifier:11723473] PDB:3SQP [DatabaseIdentifier:11723500] PDB:4GR1 [DatabaseIdentifier:11723516] PDB:4GRT [DatabaseIdentifier:11723542] PDB:5GRT [DatabaseIdentifier:11809388] PRO:P00390 [DatabaseIdentifier:11845207] GeneCards:P00390 [DatabaseIdentifier:11852910] ZINC - Substances:GSHR_HUMAN [DatabaseIdentifier:11855399] ZINC - FDA approved:GSHR_HUMAN [DatabaseIdentifier:11856450] ZINC - World Drugs:GSHR_HUMAN [DatabaseIdentifier:11860690] ZINC - Predictions - Purchasable:GSHR_HUMAN [DatabaseIdentifier:11863767] ZINC target:P00390 [DatabaseIdentifier:11881645] Orphanet:16171 [DatabaseIdentifier:11893512] HPA:ENSG00000104687-GSR [DatabaseIdentifier:12027051] Ensembl:ENST00000537535 [DatabaseIdentifier:12027052] Ensembl:ENST00000546342 [DatabaseIdentifier:12027053] Ensembl:ENSG00000104687 [DatabaseIdentifier:12027054] Ensembl:ENSP00000438845 [DatabaseIdentifier:12027055] Ensembl:ENST00000221130 [DatabaseIdentifier:12027056] Ensembl:ENSP00000444559 [DatabaseIdentifier:12027057] Ensembl:ENSP00000445516 [DatabaseIdentifier:12027058] Ensembl:ENSP00000221130 [DatabaseIdentifier:12027059] Ensembl:ENST00000541648
databaseName	UniProt
dbId	231279
description	recommendedName: Glutathione reductase, mitochondrial shortName: GR shortName: GRase ecNumber evidence="3"1.8.1.7
displayName	UniProt:P00390-2 GSR
geneName	GSR GLUR GRD1
identifier	P00390
isSequenceChanged	false
isoformParent	[ReferenceGeneProduct:56010] UniProt:P00390 GSR
keyword	3D-structure Acetylation Alternative initiation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Disulfide bond FAD Flavoprotein Hereditary hemolytic anemia Mitochondrion NADP Oxidoreductase Redox-active center Reference proteome Transit peptide
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	GSR
otherIdentifier	11756634_a_at 11759080_at 17076063 205770_PM_at 205770_at 225609_PM_at 225609_at 2936 3130162 3130163 3130164 3130166 3130168 3130169 3130171 3130172 3130174 3130177 3130178 3130179 3130181 3130182 3130188 3130189 3130190 3130191 3130192 35130_at 63787_i_at 8150112 A_23_P146084 A_32_P31618 GE54991 GO:0000166 GO:0003824 GO:0004362 GO:0005576 GO:0005615 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0005886 GO:0006091 GO:0006575 GO:0006749 GO:0006790 GO:0009055 GO:0009897 GO:0016209 GO:0016491 GO:0016668 GO:0022900 GO:0034599 GO:0043226 GO:0045454 GO:0050660 GO:0050661 GO:0070062 GO:0098754 GO:0098869 GO:0140096 HMNXSV003002640 Hs.193974.0.S1_3p_at ILMN_1775182 ILMN_2127416 PH_hs_0024978 PH_hs_0033237 TC08001110.hg X15722_at g10835188_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71679] GSR-2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9003565] ENSEMBL:ENSG00000104687 GSR [ReferenceDNASequence:11030845] KEGG Gene (Homo sapiens):2936 GSR [ReferenceDNASequence:11251426] NCBI Gene:2936 GSR [ReferenceDNASequence:11251427] BioGPS Gene:2936 GSR [ReferenceDNASequence:11251428] CTD Gene:2936 GSR [ReferenceDNASequence:11251429] dbSNP Gene:2936 GSR [ReferenceDNASequence:11251430] Monarch:2936 GSR [ReferenceDNASequence:11348177] ENSEMBL_homo_sapiens_GENE:ENSG00000104687.14 GSR [ReferenceDNASequence:11514399] UCSC:P00390 GSR [ReferenceDNASequence:11797879] OMIM:138300 GSR [ReferenceDNASequence:11872562] HGNC:4623 GSR [ReferenceDNASequence:12191330] COSMIC (genes):GSR GSR
referenceTranscript	[ReferenceRNASequence:11449945] RefSeq:NM_000637.3 GSR [ReferenceRNASequence:11449963] RefSeq:NM_001195102.1 GSR [ReferenceRNASequence:11449990] RefSeq:NM_001195103.1 GSR [ReferenceRNASequence:11450016] RefSeq:NM_001195104.1 GSR
schemaClass	ReferenceIsoform
secondaryIdentifier	GSHR_HUMAN C8KIL8 C8KIL9 C8KIM0 D3DSV3 Q7Z5C9 Q9NP63
sequenceLength	522
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P00390-2
variantIdentifier	P00390-2

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-71679] GSR-2 [cytosol]

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