UniProt:A0FGR9 ESYT3

chain
  • chain:1-886
checksum 5CFE68F790D11B9B
comment
  • FUNCTION Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.SUBUNIT Interacts with ESYT1 and ESYT2.INTERACTION Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:30220461). Recruited to the cell membrane via the third C2 domain.ALTERNATIVE PRODUCTS Widely expressed with high level in cerebellum and skin.DOMAIN Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.DOMAIN The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (By similarity). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (PubMed:23791178).DOMAIN The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).SIMILARITY Belongs to the extended synaptotagmin family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228568
description
  • recommendedName: fullName evidence="15"Extended synaptotagmin-3 shortName evidence="14"E-Syt3 alternativeName: Chr3Syt
displayName UniProt:A0FGR9 ESYT3
geneName
  • ESYT3
  • FAM62C
identifier A0FGR9
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Endoplasmic reticulum
  • Lipid transport
  • Lipid-binding
  • Membrane
  • Metal-binding
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ESYT3
otherIdentifier
  • 11732507_a_at
  • 11732508_s_at
  • 11751965_s_at
  • 1554912_PM_at
  • 1554912_at
  • 16946173
  • 239770_PM_at
  • 239770_at
  • 2644620
  • 2644621
  • 2644625
  • 2644630
  • 2644632
  • 2644635
  • 2644636
  • 2644640
  • 2644642
  • 2644644
  • 2644646
  • 2644647
  • 2644649
  • 2644651
  • 2644652
  • 2644654
  • 2644655
  • 2644656
  • 2644660
  • 2644663
  • 2644664
  • 2644665
  • 2644666
  • 2644667
  • 2644668
  • 2644669
  • 2644670
  • 2644671
  • 2644672
  • 2644673
  • 2644674
  • 2644676
  • 2644677
  • 2644679
  • 2644680
  • 2644681
  • 2644682
  • 2644683
  • 2644685
  • 2644687
  • 2644689
  • 80400_at
  • 8082974
  • 83850
  • 90602_i_at
  • A_24_P350786
  • A_24_P697685
  • A_33_P3238280
  • GE507080
  • GE542298
  • GO:0005509
  • GO:0005515
  • GO:0005544
  • GO:0005783
  • GO:0005789
  • GO:0005886
  • GO:0006869
  • GO:0008289
  • GO:0008429
  • GO:0009898
  • GO:0016020
  • GO:0031210
  • GO:0031234
  • GO:0035091
  • GO:0043226
  • GO:0044232
  • GO:0046872
  • GO:0061817
  • GO:0140268
  • HMNXSV003021432
  • HMNXSV003057298
  • Hs.148369.0.A1_3p_at
  • Hs2.318921.1.S1_3p_at
  • ILMN_1745764
  • PH_hs_0016009
  • TC03000745.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ESYT3_HUMAN
  • A8K0G5
  • Q6ZV21
  • Q8NDZ5
  • Q9BQR9
sequenceLength 886
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A0FGR9
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