UniProt:A0FGR8 ESYT2

chain
  • chain:1-921
checksum D57F1BD9BB0A0C8A
comment
  • FUNCTION Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).SUBUNIT Homodimer. Interacts with ESYT1 and ESYT3. Interacts with FGFR1 that has been activated by FGF1 binding. Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1.INTERACTION Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).ALTERNATIVE PRODUCTS Widely expressed with high level in cerebellum.DOMAIN Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.DOMAIN The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (PubMed:24373768). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for location at the cell membrane (PubMed:23791178).DOMAIN The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (PubMed:24847877).SIMILARITY Belongs to the extended synaptotagmin family.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228561
description
  • recommendedName: fullName evidence="19"Extended synaptotagmin-2 shortName evidence="17"E-Syt2 alternativeName: Chr2Syt
displayName UniProt:A0FGR8 ESYT2
geneName
  • ESYT2
  • FAM62B
  • KIAA1228
identifier A0FGR8
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Endocytosis
  • Endoplasmic reticulum
  • Lipid transport
  • Lipid-binding
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ESYT2
otherIdentifier
  • 11721313_a_at
  • 11721314_at
  • 1555830_PM_s_at
  • 1555830_s_at
  • 1558511_PM_s_at
  • 1558511_s_at
  • 17064984
  • 224698_3p_at
  • 224698_PM_at
  • 224698_at
  • 224699_PM_s_at
  • 224699_s_at
  • 3082250
  • 3082251
  • 3082252
  • 3082253
  • 3082254
  • 3082256
  • 3082258
  • 3082259
  • 3082262
  • 3082263
  • 3082264
  • 3082265
  • 3082266
  • 3082271
  • 3082275
  • 3082277
  • 3082278
  • 3082286
  • 3082287
  • 3082288
  • 3082289
  • 3082291
  • 3082294
  • 3082295
  • 3082301
  • 3082302
  • 3082306
  • 3082308
  • 3082309
  • 3082318
  • 3082319
  • 3082320
  • 3082321
  • 3082322
  • 3082323
  • 56288_at
  • 57488
  • 59648_at
  • 63801_at
  • 8144184
  • A_23_P8744
  • A_24_P132470
  • GE80288
  • GO:0005509
  • GO:0005515
  • GO:0005544
  • GO:0005783
  • GO:0005789
  • GO:0005829
  • GO:0005886
  • GO:0006869
  • GO:0006897
  • GO:0008289
  • GO:0008429
  • GO:0009898
  • GO:0016020
  • GO:0016192
  • GO:0031210
  • GO:0031234
  • GO:0035091
  • GO:0042802
  • GO:0043226
  • GO:0044232
  • GO:0045296
  • GO:0046872
  • GO:0061817
  • GO:0140268
  • HMNXSV003011517
  • Hs.267690.1.A1_3p_s_at
  • Hs.267690.1.A2_3p_x_at
  • Hs2.407397.1.A1_3p_s_at
  • Hs2Affx.1.469.A1_3p_s_at
  • ILMN_2057573
  • PH_hs_0024446
  • TC07002084.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ESYT2_HUMAN
  • A4D229
  • Q69YJ2
  • Q6UKI4
  • Q6ZTU0
  • Q6ZVU1
  • Q9BQS0
  • Q9NW47
  • Q9ULJ2
sequenceLength 921
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A0FGR8
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