UniProt:A1L3X0 ELOVL7

chain
  • initiator methionine:
  • chain:2-281
checksum 33C3DA79704F6E9F
comment
  • FUNCTION Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.CATALYTIC ACTIVITY a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoACATALYTIC ACTIVITY eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoABIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; fatty acid biosynthesis.SUBUNIT Homodimer.INTERACTION Expressed in most tissues except heart and skeletal muscle.DOMAIN The C-terminal di-lysine motif may confer endoplasmic reticulum localization.SIMILARITY Belongs to the ELO family. ELOVL7 subfamily.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated C-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228208
description
  • recommendedName: fullName evidence="1"Very long chain fatty acid elongase 7 ecNumber evidence="1 3 4 5"2.3.1.199 alternativeName: fullName evidence="1"3-keto acyl-CoA synthase ELOVL7 alternativeName: fullName evidence="1"ELOVL fatty acid elongase 7 shortName evidence="1"ELOVL FA elongase 7 alternativeName: fullName evidence="1"Elongation of very long chain fatty acids protein 7 alternativeName: fullName evidence="1"Very long chain 3-ketoacyl-CoA synthase 7 alternativeName: fullName evidence="1"Very long chain 3-oxoacyl-CoA synthase 7
displayName UniProt:A1L3X0 ELOVL7
geneName
  • ELOVL7
identifier A1L3X0
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Disulfide bond
  • Endoplasmic reticulum
  • Fatty acid biosynthesis
  • Fatty acid metabolism
  • Lipid biosynthesis
  • Lipid metabolism
  • Membrane
  • Reference proteome
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ELOVL7
otherIdentifier
  • 11738047_a_at
  • 11738048_a_at
  • 11758577_s_at
  • 16996564
  • 227180_PM_at
  • 227180_at
  • 2858639
  • 2858640
  • 2858641
  • 2858642
  • 2858643
  • 2858645
  • 2858647
  • 2858650
  • 2858655
  • 2858657
  • 2858658
  • 79993
  • 8112274
  • A_23_P359277
  • A_24_P32473
  • GE86945
  • GO:0003824
  • GO:0005515
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0006631
  • GO:0006633
  • GO:0006636
  • GO:0006790
  • GO:0009922
  • GO:0016020
  • GO:0016740
  • GO:0019367
  • GO:0030148
  • GO:0030497
  • GO:0034625
  • GO:0034626
  • GO:0035338
  • GO:0042761
  • GO:0043226
  • GO:0055086
  • GO:1901135
  • HMNXSV003024746
  • Hs.274256.0.S1_3p_at
  • ILMN_1740213
  • PH_hs_0014130
  • TC05001393.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ELOV7_HUMAN
  • Q589T3
  • Q9H5D0
  • Q9NT66
sequenceLength 281
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A1L3X0
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