UniProt:A5X5Y0 HTR3E

chain
  • signal peptide:1-25
  • chain:26-456
checksum 4BFA6561BA309E83
comment
  • FUNCTION Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)SUBUNIT Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3A. The homomeric complex is not functional. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo.INTERACTION Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.ALTERNATIVE PRODUCTS Expressed in adult colon and intestine.DOMAIN The HA-stretch region of HTR3E seems to confer increased conductance to HTR3A/HTR3E heteropentamers compared to that of HTR3A homopentamers.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 217433
description
  • recommendedName: fullName evidence="15"5-hydroxytryptamine receptor 3E shortName: 5-HT3-E shortName: 5-HT3E alternativeName: Serotonin receptor 3E
displayName UniProt:A5X5Y0 HTR3E
geneName
  • HTR3E
identifier A5X5Y0
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ion channel
  • Ion transport
  • Ligand-gated ion channel
  • Membrane
  • Postsynaptic cell membrane
  • Receptor
  • Reference proteome
  • Signal
  • Synapse
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • HTR3E
otherIdentifier
  • 11738477_a_at
  • 11738478_x_at
  • 11745683_a_at
  • 11752389_a_at
  • 16948659
  • 2655319
  • 2655320
  • 2655321
  • 2655347
  • 2655349
  • 2655350
  • 2655351
  • 2655352
  • 2655353
  • 2655354
  • 2655355
  • 2655356
  • 2655357
  • 2655358
  • 2655359
  • 2655360
  • 2655361
  • 2655363
  • 2655364
  • 2655365
  • 2655366
  • 285242
  • 8084284
  • GO:0004888
  • GO:0005215
  • GO:0005216
  • GO:0005230
  • GO:0005515
  • GO:0005886
  • GO:0006811
  • GO:0007210
  • GO:0016020
  • GO:0022848
  • GO:0022850
  • GO:0023052
  • GO:0034220
  • GO:0043005
  • GO:0045202
  • GO:0045211
  • GO:0050877
  • GO:0055085
  • GO:0060078
  • GO:0060079
  • GO:0060089
  • GO:0098662
  • GO:1904602
  • HMNXSV003015123
  • ILMN_1778277
  • PH_hs_0026242
  • TC03000991.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 5HT3E_HUMAN
  • A8IKD7
  • E9PGF1
  • Q495G1
  • Q495G3
  • Q6V706
  • Q6V707
  • Q7Z6B2
sequenceLength 456
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A5X5Y0
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