UniProt:A1A4S6 ARHGAP10

chain
  • chain:1-786
checksum 7D7006CEAC0094BD
comment
  • FUNCTION GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433).SUBUNIT Interacts with PKN3 (PubMed:11432776). Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect GRAF2/ARHGAP10 GTPase activation activity towards RHOA and CDC42 (By similarity). Interacts via its SH3 domain with PTK2/FAK1 (By similarity). Interacts with PTK2B/PYK2; the interaction negatively regulates GRAF2/ARHGAP10 GTPase-activating activity (By similarity). Interacts with MICAL1 and WDR44; complex formation might transit from GRAF2/ARHGAP10-MICAL1 to GRAF2/ARHGAP10-WDR44 complexes (PubMed:32344433).INTERACTION Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433).TISSUE SPECIFICITY High levels of expression in heart and skeletal muscle.DOMAIN The BAR domain is important to associate RAB8A (or RAB8B) and RAB10 to endosomal membrane to promote tubule extension. The BAR domain is also important to recruit WDR44 to endosomal tubules.PTM Phosphorylated. Phosphorylated in vitro by constitutive active PKN3.
created [InstanceEdit:211700] Matthews, L, 2008-02-08 00:48:41
crossReference
databaseName UniProt
dbId 211699
description
  • recommendedName: Rho GTPase-activating protein 10 alternativeName: GTPase regulator associated with focal adhesion kinase 2 shortName evidence="9"GRAF2 alternativeName: Graf-related protein 2 alternativeName: Rho-type GTPase-activating protein 10
displayName UniProt:A1A4S6 ARHGAP10
geneName
  • ARHGAP10
  • GRAF2
identifier A1A4S6
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Cytoplasm
  • Endosome
  • GTPase activation
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • SH3 domain
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ARHGAP10
otherIdentifier
  • 11758155_s_at
  • 16971308
  • 219431_PM_at
  • 219431_at
  • 2746694
  • 2746695
  • 2746719
  • 2746720
  • 2746724
  • 2746726
  • 2746731
  • 2746736
  • 2746741
  • 2746744
  • 2746748
  • 2746751
  • 2746752
  • 2746753
  • 2746763
  • 2746767
  • 2746769
  • 2746770
  • 2746771
  • 2746783
  • 2746784
  • 2746788
  • 2746792
  • 2746794
  • 2746800
  • 2746801
  • 2746802
  • 2746803
  • 2746804
  • 2746805
  • 2746806
  • 43984_at
  • 79658
  • 8097717
  • GE87412
  • GO:0005096
  • GO:0005515
  • GO:0005737
  • GO:0005768
  • GO:0005829
  • GO:0005886
  • GO:0007010
  • GO:0007165
  • GO:0010008
  • GO:0012501
  • GO:0016020
  • GO:0023052
  • GO:0031410
  • GO:0043066
  • GO:0043226
  • GO:0048471
  • GO:0051056
  • GO:0098772
  • HMNXSV003038131
  • HMNXSV003045174
  • ILMN_1736112
  • PH_hs_0002362
  • PH_hs_0031658
  • TC04000733.hg
  • g13375810_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RHG10_HUMAN
  • A1L0S5
  • Q2VPC4
  • Q2VPC5
  • Q96EV3
  • Q96S75
sequenceLength 786
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/A1A4S6
Cite Us!