UniProt:O00204-1 SULT2B1

chain
  • chain:1-365
checksum 13E95248DD40DF91
comment
  • FUNCTION Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).FUNCTION Sulfonates pregnenolone but not cholesterol.CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)CATALYTIC ACTIVITY (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfateBIOPHYSICOCHEMICAL PROPERTIES Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius.INTERACTION Phosphorylation of Ser-348 is required for translocation to the nucleus.ALTERNATIVE PRODUCTS Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594).DOMAIN The C-terminus, which contains a proline/serine-rich region is involved in nuclear translocation and enzymatic thermostability.PTM Phosphorylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sulfotransferase 1 family.
created [InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01
crossReference
databaseName UniProt
dbId 176587
description
  • recommendedName: Sulfotransferase 2B1 ecNumber evidence="3 4 5 6 7 9"2.8.2.2 alternativeName: Alcohol sulfotransferase alternativeName: Hydroxysteroid sulfotransferase 2 alternativeName: Sulfotransferase family 2B member 1 alternativeName: Sulfotransferase family cytosolic 2B member 1 shortName: ST2B1
displayName UniProt:O00204-1 SULT2B1
geneName
  • SULT2B1
  • HSST2
identifier O00204
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Disease variant
  • Endoplasmic reticulum
  • Ichthyosis
  • Lipid metabolism
  • Microsome
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Steroid metabolism
  • Transferase
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • SULT2B1
otherIdentifier
  • 11729444_a_at
  • 16863820
  • 205759_PM_s_at
  • 205759_s_at
  • 3837867
  • 3837868
  • 3837869
  • 3837870
  • 3837871
  • 3837872
  • 3837873
  • 3837875
  • 3837876
  • 3837877
  • 3837878
  • 3837879
  • 3837880
  • 41034_s_at
  • 6820
  • 8030067
  • GE81418
  • GO:0003676
  • GO:0003824
  • GO:0004027
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005634
  • GO:0005737
  • GO:0005783
  • GO:0005829
  • GO:0006629
  • GO:0006790
  • GO:0008146
  • GO:0008202
  • GO:0008203
  • GO:0008285
  • GO:0008289
  • GO:0015485
  • GO:0016740
  • GO:0030154
  • GO:0036094
  • GO:0043226
  • GO:0043231
  • GO:0045606
  • GO:0048856
  • GO:0050294
  • GO:0050427
  • GO:0051922
  • GO:0051923
  • GO:0055086
  • GO:0070062
  • GO:1901135
  • GO:1990239
  • HMNXSV003049139
  • ILMN_1705674
  • ILMN_1727589
  • ILMN_1763520
  • PH_hs_0019360
  • TC19000705.hg
  • U92314_s_at
  • g4759191_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • ST2B1_HUMAN
  • O00205
  • O75814
sequenceLength 365
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O00204-1
variantIdentifier O00204-1
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