Reactome | *Plk1 is shown to phosphorylate Wee1A, an event that is like...

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created	[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
dbId	156684
displayName	*Plk1 is shown to phosphorylate Wee1A, an event that is like...
literatureReference	[LiteratureReference:162979] Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer [LiteratureReference:162972] Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase
modified	[InstanceEdit:349581] Matthews, L, 2008-05-11 23:49:32
schemaClass	Summation
text	Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. * Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry.

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