UniProt:O75916-3 RGS9

chain
  • chain:1-674
checksum 8E2B11104B448364
comment
  • FUNCTION Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).SUBUNIT Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.SUBCELLULAR LOCATION Isoform 3 is targeted to the membrane via its interaction with RGS9BP.ALTERNATIVE PRODUCTS Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).DOMAIN In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.PTM Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 152926
description
  • recommendedName: Regulator of G-protein signaling 9 shortName: RGS9
displayName UniProt:O75916-3 RGS9
geneName
  • RGS9
identifier O75916
isSequenceChanged false
isoformParent
keyword
  • Alternative splicing
  • Disease variant
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • Sensory transduction
  • Signal transduction inhibitor
  • Vision
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • RGS9
otherIdentifier
  • 11723132_a_at
  • 11723133_at
  • 11752972_a_at
  • 16837101
  • 206518_PM_s_at
  • 206518_s_at
  • 35112_at
  • 3731544
  • 3731545
  • 3731548
  • 3731551
  • 3731553
  • 3731554
  • 3731555
  • 3731556
  • 3731559
  • 3731569
  • 3731576
  • 3731577
  • 3731580
  • 3731583
  • 3731587
  • 3731589
  • 3731590
  • 3731596
  • 3731612
  • 3731613
  • 3731614
  • 3731615
  • 8009277
  • 8787
  • A_23_P66881
  • GE54674
  • GO:0001975
  • GO:0003824
  • GO:0003924
  • GO:0005096
  • GO:0005737
  • GO:0005886
  • GO:0007186
  • GO:0007212
  • GO:0007399
  • GO:0007601
  • GO:0008277
  • GO:0009968
  • GO:0016020
  • GO:0016787
  • GO:0023052
  • GO:0032355
  • GO:0035556
  • GO:0036367
  • GO:0042734
  • GO:0043005
  • GO:0043226
  • GO:0048856
  • GO:0050877
  • GO:0050896
  • GO:0055085
  • GO:0098772
  • GO:0098839
  • GO:0098978
  • GO:1905912
  • GO:1990603
  • HMNXSV003036179
  • ILMN_1754468
  • ILMN_2389984
  • PH_hs_0006422
  • TC17000781.hg
  • g4506520_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • RGS9_HUMAN
  • A8K3C0
  • O75573
  • Q696R2
  • Q8TD64
  • Q8TD65
  • Q9HC32
  • Q9HC33
sequenceLength 674
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O75916-3
variantIdentifier O75916-3
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