UniProt:O43157-1 PLXNB1

chain
  • signal peptide:1-19
  • chain:20-2135
checksum 12A81B68AF1D340F
comment
  • FUNCTION Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496).SUBUNIT Monomer, and heterodimer with PLXNB2 after proteolytic processing (PubMed:12533544, PubMed:17916560, PubMed:18411422, PubMed:18275816, PubMed:19843518, PubMed:20877282, PubMed:21912513). Binds RAC1 that has been activated by GTP binding (PubMed:11035813, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interaction with SEMA4D promotes binding of cytoplasmic ligands (PubMed:10520995, PubMed:12198496, PubMed:19843518). Interacts with PLXNA1 (By similarity). Interacts with ARHGEF11 and ARHGEF12 (PubMed:12196628). Interacts with ERBB2 (PubMed:15210733). Interacts with MET (PubMed:12198496, PubMed:15184888). Interacts with MST1R (PubMed:15184888). Interacts with RRAS (PubMed:19843518). Interacts with RHOD (PubMed:17916560). Interacts with RND1 (PubMed:12730235, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interacts with NRP1 and NRP2 (PubMed:10520995).INTERACTION Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.PTM Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.PTM Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.SIMILARITY Belongs to the plexin family.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 152655
description
  • recommendedName: Plexin-B1 alternativeName: Semaphorin receptor SEP
displayName UniProt:O43157-1 PLXNB1
geneName
  • PLXNB1
  • KIAA0407
  • PLXN5
  • SEP
identifier O43157
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Coiled coil
  • Disulfide bond
  • Glycoprotein
  • Membrane
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • PLXNB1
otherIdentifier
  • 11749426_a_at
  • 11754713_a_at
  • 16953329
  • 215668_PM_s_at
  • 215668_s_at
  • 215807_PM_s_at
  • 215807_s_at
  • 2673182
  • 2673183
  • 2673184
  • 2673185
  • 2673186
  • 2673188
  • 2673191
  • 2673192
  • 2673194
  • 2673197
  • 2673198
  • 2673200
  • 2673201
  • 2673203
  • 2673205
  • 2673206
  • 2673207
  • 2673208
  • 2673209
  • 2673210
  • 2673211
  • 2673212
  • 2673213
  • 2673214
  • 2673215
  • 2673216
  • 2673217
  • 2673220
  • 2673221
  • 2673222
  • 2673224
  • 2673225
  • 2673226
  • 2673227
  • 2673228
  • 2673229
  • 2673230
  • 2673231
  • 2673232
  • 2673233
  • 2673234
  • 2673235
  • 2673236
  • 2673237
  • 2673238
  • 2673239
  • 2673240
  • 2673241
  • 2673243
  • 2673244
  • 2673245
  • 2673246
  • 2673248
  • 2673249
  • 2673250
  • 2673251
  • 2673252
  • 2673253
  • 2673255
  • 2673256
  • 33783_at
  • 5364
  • 8086908
  • A_23_P57961
  • GE81179
  • GO:0002116
  • GO:0004888
  • GO:0005096
  • GO:0005515
  • GO:0005576
  • GO:0005886
  • GO:0007010
  • GO:0007155
  • GO:0007162
  • GO:0008360
  • GO:0016020
  • GO:0016477
  • GO:0017154
  • GO:0023052
  • GO:0030154
  • GO:0030215
  • GO:0030334
  • GO:0032794
  • GO:0033689
  • GO:0034330
  • GO:0035025
  • GO:0035556
  • GO:0043547
  • GO:0043931
  • GO:0048812
  • GO:0048856
  • GO:0048870
  • GO:0050772
  • GO:0051493
  • GO:0051897
  • GO:0060089
  • GO:0071526
  • GO:0098772
  • GO:1902287
  • GO:1904862
  • HMNXSV003001085
  • Hs.278311.1.S1_3p_a_at
  • Hs.312939.0.S1_3p_s_at
  • ILMN_1742330
  • PH_hs_0014265
  • TC03001378.hg
  • X87904_at
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • PLXB1_HUMAN
  • A6H8Y2
  • Q6NY20
  • Q9UIV7
  • Q9UJ92
  • Q9UJ93
sequenceLength 2135
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O43157-1
variantIdentifier O43157-1
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