Reactome | UniProt:O43561-2 LAT

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UniProt:O43561-2 LAT Show undefined attributes

chain	chain:1-262
checksum	BCD80AE7DCA64153
comment	FUNCTION Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:25907557, PubMed:23514740). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.SUBUNIT When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).SUBUNIT (Microbial infection) Interacts with herpes virus 1/HHV-1 protein US3; this interaction prevents the interaction between LAT and TRAF6.INTERACTION Present in lipid rafts.ALTERNATIVE PRODUCTS Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).PTM Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.PTM Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.PTM 'Lys-63'-linked ubiquitinated by TRAF6.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.
crossReference	[DatabaseIdentifier:10972765] Pharos - Targets:O43561 [DatabaseIdentifier:11054155] OpenTargets:ENSG00000213658 [DatabaseIdentifier:11603832] RefSeq:NP_001014987.1 [DatabaseIdentifier:11603846] RefSeq:NP_001014988.1 [DatabaseIdentifier:11603860] RefSeq:NP_001014989.2 [DatabaseIdentifier:11603872] RefSeq:NP_055202.1 [DatabaseIdentifier:11812728] PRO:O43561 [DatabaseIdentifier:11844302] GeneCards:O43561 [DatabaseIdentifier:11881886] Orphanet:26797 [DatabaseIdentifier:11894908] HPA:ENSG00000213658-LAT [DatabaseIdentifier:12008023] Ensembl:ENSG00000213658 [DatabaseIdentifier:12008024] Ensembl:ENSP00000354119 [DatabaseIdentifier:12008025] Ensembl:ENSP00000398793 [DatabaseIdentifier:12008026] Ensembl:ENST00000395456 [DatabaseIdentifier:12008027] Ensembl:ENSP00000378845 [DatabaseIdentifier:12008028] Ensembl:ENSP00000456761 [DatabaseIdentifier:12008029] Ensembl:ENSP00000457036 [DatabaseIdentifier:12008030] Ensembl:ENST00000454369 [DatabaseIdentifier:12008031] Ensembl:ENSP00000378841 [DatabaseIdentifier:12008032] Ensembl:ENST00000395461 [DatabaseIdentifier:12008033] Ensembl:ENST00000564277 [DatabaseIdentifier:12008034] Ensembl:ENST00000566177 [DatabaseIdentifier:12008035] Ensembl:ENST00000360872
databaseName	UniProt
dbId	149573
description	recommendedName: Linker for activation of T-cells family member 1 alternativeName: 36 kDa phosphotyrosine adapter protein shortName: pp36 alternativeName: p36-38
displayName	UniProt:O43561-2 LAT
geneName	LAT
identifier	O43561
isSequenceChanged	false
isoformParent	[ReferenceGeneProduct:58417] UniProt:O43561 LAT
keyword	Adaptive immunity Alternative splicing Cell membrane Direct protein sequencing Immunity Lipoprotein Mast cell degranulation Membrane Palmitate Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	LAT
otherIdentifier	11726777_a_at 11743748_a_at 16817537 209881_PM_s_at 209881_s_at 211005_PM_at 211005_at 27040 3654964 3654965 3654966 3654967 3654969 3654970 3654972 3654974 3654975 3654976 3654977 3654978 3654981 3654983 3654984 3654985 3654986 3654987 40688_at 7994535 7994541 A_23_P44105 A_23_P44112 GE55241 GE81922 GO:0001772 GO:0002250 GO:0002260 GO:0002376 GO:0005515 GO:0005634 GO:0005794 GO:0005886 GO:0005911 GO:0006954 GO:0006955 GO:0007165 GO:0007229 GO:0007265 GO:0008180 GO:0010467 GO:0016020 GO:0016192 GO:0019722 GO:0019901 GO:0023052 GO:0030159 GO:0035556 GO:0036211 GO:0042110 GO:0043226 GO:0043303 GO:0045121 GO:0045860 GO:0048872 GO:0050852 GO:0050863 GO:0060090 HMNXSV003017433 ILMN_1691539 ILMN_1750188 ILMN_2281320 ILMN_2404625 PH_hs_0026523 PH_hs_0034136 g2828023_3p_a_at g2828025_3p_at p33449 p33450
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2396597] p-5Y-LAT-2 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2396548] LAT-2 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9003618] ENSEMBL:ENSG00000213658 LAT [ReferenceDNASequence:11024467] KEGG Gene (Homo sapiens):27040 LAT [ReferenceDNASequence:11248466] NCBI Gene:27040 LAT [ReferenceDNASequence:11248467] BioGPS Gene:27040 LAT [ReferenceDNASequence:11248468] CTD Gene:27040 LAT [ReferenceDNASequence:11248469] dbSNP Gene:27040 LAT [ReferenceDNASequence:11248470] Monarch:27040 LAT [ReferenceDNASequence:11347578] ENSEMBL_homo_sapiens_GENE:ENSG00000213658.13 LAT [ReferenceDNASequence:11513656] UCSC:O43561 LAT [ReferenceDNASequence:11793823] OMIM:602354 LAT [ReferenceDNASequence:11871656] HGNC:18874 LAT [ReferenceDNASequence:12194627] COSMIC (genes):LAT LAT
referenceTranscript	[ReferenceRNASequence:11450560] RefSeq:NM_001014987.1 LAT [ReferenceRNASequence:11450572] RefSeq:NM_001014988.1 LAT [ReferenceRNASequence:11450585] RefSeq:NM_001014989.1 LAT [ReferenceRNASequence:11450598] RefSeq:NM_014387.3 LAT
schemaClass	ReferenceIsoform
secondaryIdentifier	LAT_HUMAN B7WPI0 C7C5T6 G5E9K3 O43919
sequenceLength	262
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/O43561-2
variantIdentifier	O43561-2

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2396597] p-5Y-LAT-2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2396548] LAT-2 [plasma membrane]
(referenceSequence)	[ModifiedResidue:2396595] O4'-phospho-L-tyrosine at 226 [ModifiedResidue:2396588] O4'-phospho-L-tyrosine at 127 [ModifiedResidue:2396590] O4'-phospho-L-tyrosine at 132 [ModifiedResidue:2396553] O4'-phospho-L-tyrosine at 191 [ModifiedResidue:2396603] O4'-phospho-L-tyrosine at 171
(interactor)	[UndirectedInteraction:12237149] UniProt:O43561-2 <-> UniProt:Q8N6L0 (IntAct) [UndirectedInteraction:12237147] UniProt:O43561-2 <-> UniProt:P08487 (IntAct) [UndirectedInteraction:12237143] UniProt:O43561-2 <-> UniProt:P43628 (IntAct) [UndirectedInteraction:12237141] UniProt:O43561-2 <-> UniProt:P48165 (IntAct) [UndirectedInteraction:12237139] UniProt:O43561-2 <-> UniProt:Q86WI0 (IntAct) [UndirectedInteraction:12237135] UniProt:O43561-2 <-> UniProt:Q8TDT2 (IntAct) [UndirectedInteraction:12237133] UniProt:O43561-2 <-> UniProt:P07307-3 (IntAct) [UndirectedInteraction:12237131] UniProt:O43561-2 <-> UniProt:Q9Y680 (IntAct) [UndirectedInteraction:12237129] UniProt:O43561-2 <-> UniProt:Q96MG2 (IntAct) [UndirectedInteraction:12237125] UniProt:O43561-2 <-> IntAct:EBI-23641393 (IntAct) [UndirectedInteraction:12237123] UniProt:O43561-2 <-> UniProt:Q8NBJ4 (IntAct) [UndirectedInteraction:12237121] UniProt:O43561-2 <-> UniProt:Q8N183 (IntAct) [UndirectedInteraction:12237119] UniProt:O43561-2 <-> IntAct:EBI-23184686 (IntAct) [UndirectedInteraction:12237115] UniProt:O43561-2 <-> UniProt:J3KQ12 (IntAct) [UndirectedInteraction:12237113] UniProt:O43561-2 <-> UniProt:Q6N075 (IntAct) [UndirectedInteraction:12237111] UniProt:O43561-2 <-> UniProt:Q8TAF8 (IntAct) [UndirectedInteraction:12237109] UniProt:O43561-2 <-> UniProt:Q9GZW8 (IntAct) [UndirectedInteraction:12237105] UniProt:O43561-2 <-> UniProt:Q96BI3 (IntAct) [UndirectedInteraction:12237103] UniProt:O43561-2 <-> UniProt:Q9BZV2 (IntAct) [UndirectedInteraction:12237101] UniProt:O43561-2 <-> UniProt:Q9NXF8-2 (IntAct) [UndirectedInteraction:12237097] UniProt:O43561-2 <-> UniProt:Q15849 (IntAct) [UndirectedInteraction:12237095] UniProt:O43561-2 <-> UniProt:P03973 (IntAct) [UndirectedInteraction:12237093] UniProt:O43561-2 <-> UniProt:P19397 (IntAct) [UndirectedInteraction:12237091] UniProt:O43561-2 <-> UniProt:Q8N9I0 (IntAct) [UndirectedInteraction:12237089] UniProt:O43561-2 <-> UniProt:O14843 (IntAct) [UndirectedInteraction:12237087] UniProt:O43561-2 <-> UniProt:Q96HE8 (IntAct) [UndirectedInteraction:12237085] UniProt:O43561-2 <-> IntAct:EBI-23642082 (IntAct) [UndirectedInteraction:12237081] UniProt:O43561-2 <-> UniProt:Q16378 (IntAct) [UndirectedInteraction:12237077] UniProt:O43561-2 <-> UniProt:P09693 (IntAct) [UndirectedInteraction:12237075] UniProt:O43561-2 <-> UniProt:Q9BXS9-3 (IntAct) [UndirectedInteraction:12237073] UniProt:O43561-2 <-> UniProt:Q8N5Z5 (IntAct) [UndirectedInteraction:12237071] UniProt:O43561-2 <-> UniProt:O75712 (IntAct) [UndirectedInteraction:12237069] UniProt:O43561-2 <-> UniProt:Q5JRM2 (IntAct) [UndirectedInteraction:12237065] UniProt:O43561-2 <-> UniProt:Q8WY91 (IntAct) [UndirectedInteraction:12237061] UniProt:O43561-2 <-> UniProt:Q9BXW4 (IntAct) [UndirectedInteraction:12237059] UniProt:O43561-2 <-> UniProt:P57739 (IntAct) [UndirectedInteraction:12237057] UniProt:O43561-2 <-> UniProt:Q9GZY8-5 (IntAct) [UndirectedInteraction:12237055] UniProt:O43561-2 <-> UniProt:P49069 (IntAct) [UndirectedInteraction:12237053] UniProt:O43561-2 <-> UniProt:Q96EQ0 (IntAct) [UndirectedInteraction:12237051] UniProt:O43561-2 <-> UniProt:A8MZ59 (IntAct) [UndirectedInteraction:12237049] UniProt:O43561-2 <-> UniProt:Q8TDV0 (IntAct) [UndirectedInteraction:12237047] UniProt:O43561-2 <-> UniProt:P35372-10 (IntAct) [UndirectedInteraction:12237045] UniProt:O43561-2 <-> UniProt:Q8WWF3 (IntAct) [UndirectedInteraction:12237043] UniProt:O43561-2 <-> UniProt:Q86UW2 (IntAct) [UndirectedInteraction:12237041] UniProt:O43561-2 <-> UniProt:Q9UBN6 (IntAct) [UndirectedInteraction:12237039] UniProt:O43561-2 <-> UniProt:Q96B21 (IntAct) [UndirectedInteraction:12237037] UniProt:O43561-2 <-> UniProt:O15529 (IntAct) [UndirectedInteraction:12237035] UniProt:O43561-2 <-> UniProt:Q9NQQ7-3 (IntAct) [UndirectedInteraction:12237033] UniProt:O43561-2 <-> UniProt:Q9BQA9 (IntAct) [UndirectedInteraction:12237031] UniProt:O43561-2 <-> UniProt:O95471 (IntAct) [UndirectedInteraction:12237029] UniProt:O43561-2 <-> UniProt:Q5SR56 (IntAct) [UndirectedInteraction:12237027] UniProt:O43561-2 <-> UniProt:Q96CE8 (IntAct) [UndirectedInteraction:12237023] UniProt:O43561-2 <-> UniProt:Q96P66 (IntAct) [UndirectedInteraction:12237019] UniProt:O43561-2 <-> UniProt:O00501 (IntAct) [UndirectedInteraction:12237017] UniProt:O43561-2 <-> UniProt:Q6FHY5 (IntAct) [UndirectedInteraction:12237015] UniProt:O43561-2 <-> UniProt:Q9H2K0 (IntAct) [UndirectedInteraction:12237013] UniProt:O43561-2 <-> UniProt:Q9H305 (IntAct) [UndirectedInteraction:12237011] UniProt:O43561-2 <-> UniProt:Q96Q45-2 (IntAct) [UndirectedInteraction:12237009] UniProt:O43561-2 <-> UniProt:O43765 (IntAct) [UndirectedInteraction:12237007] UniProt:O43561-2 <-> UniProt:O15552 (IntAct) [UndirectedInteraction:12237005] UniProt:O43561-2 <-> UniProt:Q9NR31 (IntAct) [UndirectedInteraction:12237003] UniProt:O43561-2 <-> UniProt:Q9BXK5 (IntAct) [UndirectedInteraction:12236999] UniProt:O43561-2 <-> UniProt:Q9Y676 (IntAct) [UndirectedInteraction:12236997] UniProt:O43561-2 <-> UniProt:P54219-3 (IntAct) [UndirectedInteraction:12236995] UniProt:O43561-2 <-> UniProt:P62993-1 (IntAct) [UndirectedInteraction:12211171] UniProt:P08034 <-> UniProt:O43561-2 (IntAct)

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