UniProt:O75182-1 SIN3B

chain
  • chain:1-1162
checksum 03D3B24AF1CF40B6
comment
  • FUNCTION Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.SUBUNIT Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89 (PubMed:23460338). Interacts with MYT1L (By similarity).INTERACTION Ubiquitinated by RNF220 that leads to proteasomal degradation.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 101855
description
  • recommendedName: Paired amphipathic helix protein Sin3b alternativeName: Histone deacetylase complex subunit Sin3b alternativeName: Transcriptional corepressor Sin3b
displayName UniProt:O75182-1 SIN3B
geneName
  • SIN3B
  • KIAA0700
identifier O75182
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • SIN3B
otherIdentifier
  • 11716810_a_at
  • 11716811_s_at
  • 11716812_x_at
  • 11744734_a_at
  • 11746239_a_at
  • 11759689_at
  • 16859368
  • 209352_3p_s_at
  • 209352_PM_s_at
  • 209352_s_at
  • 23309
  • 3823902
  • 3823903
  • 3823904
  • 3823905
  • 3823908
  • 3823909
  • 3823910
  • 3823911
  • 3823914
  • 3823916
  • 3823918
  • 3823919
  • 3823920
  • 3823921
  • 3823922
  • 3823923
  • 3823924
  • 3823925
  • 3823929
  • 3823931
  • 3823932
  • 3823933
  • 3823935
  • 3823938
  • 3823939
  • 3823940
  • 3823943
  • 3823944
  • 3823945
  • 3823946
  • 3823947
  • 3823952
  • 39705_PM_at
  • 39705_at
  • 4881944_3p_s_at
  • 8026610
  • 90024_at
  • A_24_P93901
  • A_33_P3225230
  • GE53400
  • GE625594
  • GE84153
  • GE85101
  • GO:0000122
  • GO:0000228
  • GO:0000785
  • GO:0000805
  • GO:0000806
  • GO:0001741
  • GO:0003682
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005737
  • GO:0006351
  • GO:0006355
  • GO:0016580
  • GO:0030336
  • GO:0030849
  • GO:0043226
  • GO:0045892
  • GO:0048870
  • GO:0140110
  • HMNXSV003024979
  • Hs.13999.0.S1_3p_a_at
  • Hs.13999.0.S1_3p_s_at
  • ILMN_1788315
  • PH_hs_0001342
  • PH_hs_0041062
  • TC19000325.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • SIN3B_HUMAN
  • Q2NL91
  • Q68GC2
  • Q6P4B8
  • Q8TB34
  • Q9BSC8
sequenceLength 1162
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O75182-1
variantIdentifier O75182-1
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