Reactome | ERK1/2/5 activate RSK1/2/3

Schema > Reaction > Entries

ERK1/2/5 activate RSK1/2/3 Show undefined attributes

catalystActivity	[CatalystActivity:10000178] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10000180
displayName	ERK1/2/5 activate RSK1/2/3
eventOf	[Pathway:R-RNO-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Rattus norvegicus [Pathway:R-RNO-198753] ERK/MAPK targets - Rattus norvegicus [Pathway:R-RNO-2559582] Senescence-Associated Secretory Phenotype (SASP) - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-198746] ERK1/2/5 activate RSK1/2/3 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-RNO-199858] Ribosomal protein S6 kinase [nucleoplasm]
isInDisease	false
isInferred	true
name	ERK1/2/5 activate RSK1/2/3
output	6 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-RNO-199849] Phospho-Ribosomal protein S6 kinase [nucleoplasm]
precedingEvent	[Reaction:R-RNO-198714] ERK5 translocates to the nucleus - Rattus norvegicus [BlackBoxEvent:R-RNO-5674387] Phosphorylated MAPKs translocate into the nucleus - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-198746
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-RNO-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-RNO-198753] ERK/MAPK targets
(precedingEvent)	[Reaction:R-RNO-199895] RSK1/2/3 phosphorylates CREB at Serine 119
(inferredTo)	[Reaction:R-HSA-198746] ERK1/2/5 activate RSK1/2/3