Search results for Q96RI1

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Results (7 results from a total of 7)

Identifier: R-HSA-5340228
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1
Identifier: R-HSA-4755487
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1-2
Lysine-289 in NR1H4-1 corresponds to lysine-277 in NR1H4-2.
Identifier: R-HSA-3196157
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1-4
Identifier: R-HSA-3196161
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1-2
Identifier: R-HSA-3196171
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1-3
Identifier: R-HSA-3008624
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR1H4: Q96RI1-1
Identifier: R-HSA-4755419
Species: Homo sapiens
Compartment: nucleoplasm
NR1H4 (FXR, Bile Acid Receptor) is SUMOylated with SUMO1 at lysine-132 and lysine-289 (lysine-122 and lysine-275 of isoform 4, UniProt Q96RI1-2) (Vavassori et al. 2009, Balasubramaniyan et al. 2013). SUMOylation appears to be enhanced when NR1H4 binds ligands (Vavassori et al. 2009). SUMOylated NR1H4 transrepresses genes involved in inflammation (Vavassori et al. 2009) and inhibits ligand-induced activation of FXR targets: bile salt export pump (BSEP) and small heterodimer partner (SHP) (Balasubramaniya et al. 2013).