Search results for P27986

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Results (16 results from a total of 16)

Identifier: R-HSA-3080572
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PIK3R1: P27986
Identifier: R-HSA-2399540
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: PIK3R1: P27986
Similar to other PIK3R1 iSH2 domain mutations found in cancer, substitution of arginine residue with threonine at position 574 of PIK3R1 is expected to relieve inhibitory effect on the catalytic subunit of PI3K, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 R574T mutant (Jaiswal et al. 2009).
Identifier: R-HSA-2399536
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
Similar to other PIK3R1 iSH2 domain mutations found in cancer, substitution of arginine residue with isoleucine at position 574 of PIK3R1 is expected to relieve inhibitory effect on the catalytic subunit of PI3K, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 R574I mutant (Jaiswal et al. 2009).
Identifier: R-HSA-2399432
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The substitution of aspartic acid residue with histidine at the position 560 in the iSH2 domain of PIK3R1 is expected to relieve the inhibitory effect on the PI3K catalytic subunit, PIK3CA, and enable constitutive activity of PI3K complex that contains PIK3R1 D560H mutant, as shown for PIK3R1 D560Y mutant (Jaiswal et al. 2009).
Identifier: R-HSA-2399431
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The substitution of asparagine residue with lysine at position 564 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 N654K mutant (Sun et al. 2010).
Identifier: R-HSA-2399554
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The inframe deletion of lysine residue at position 549 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 K549del mutant (Urick et al. 2011).
Identifier: R-HSA-2399427
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The substitution of asparagine residue with aspartic acid at position 564 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 N654D mutant (Jaiswal et al. 2009).
Identifier: R-HSA-2399421
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The substitution of aspartic acid residue with tyrosine at position 560 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 D560Y mutant (Jaiswal et al. 2009).
Identifier: R-HSA-2399544
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The inframe deletion of amino acid residues at position 574 to 576 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 R574_T576del mutant (Urick et al. 2011).
Identifier: R-HSA-2399545
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The inframe deletion that removes histidine and glutamic acid residues at positions 450 and 451 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit, PIK3CA, and enables constitutive activity of PI3K complex that contains PIK3R1 H450_E451del mutant (Urick et al. 2011).
Identifier: R-HSA-2399546
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The inframe deletion of amino acid residues at position 463 to 466 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 Y463_L466del mutant (Urick et al. 2011).
Identifier: R-HSA-8944148
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
Identifier: R-HSA-2399717
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P27986
The substitution of glycine residue with arginine at position 376 in the nSH2 domain of PIK3R1 relieves the inhibitory effect on the PI3K catalytic subunit, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 G376R mutant (Sun et al. 2010).
Identifier: R-HSA-198365
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: PIK3R1: P27986
Identifier: R-HSA-74789
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P27986
Identifier: P27986-2
Species: Homo sapiens
Primary external reference: UniProt: P27986-2