Search results for P23458

Showing 7 results out of 7

×

Species

Types

Compartments

Search properties

  • clustered Search

Species

Types

Compartments

Search properties

  • clustered Search

Results (7 results from a total of 7)

Identifier: R-HSA-1112543
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: JAK1: P23458
Identifier: R-HSA-451921
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P23458
Identifier: R-HSA-8950711
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: JAK1: P23458
The receptor chains are also utilized by multiple cytokines (Fig. 1)1,2. IL-12 signals via IL12Rβ1 and IL12Rβ248,71,72, while IL-23 signals through IL12Rβ1 and IL23R69,73. In contrast, IL-27 utilizes gp130 and WSX-174, while IL-35 signals via gp130 and IL12Rβ228. IL-35 is unusual in that it can also signals via two additional receptor chain compositions; gp130-gp130 and IL12Rβ2-lL12Rβ2 homodimers28.
Signaling via all of these receptors is mediated by members of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) family27,75,76 (Fig. 1). JAK2 and either JAK1 or TYK2 appear to mediate phosphorylation of the IL-12 cytokine receptors family-associated STATs. IL-12 mediates signaling via pSTAT477, IL-23 via pSTAT3 and pSTAT469,73, IL-27 via pSTAT1 and pSTAT378,79, and IL-35 via pSTAT1 and pSTAT428. For IL-35, formation of a STAT1:STAT4 heterodimer is required for Ebi2/ Il12a transcription, but partially dispensable for supression28 (PMID:22814351)
Identifier: R-HSA-9005335
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: JAK1: P23458
Identifier: R-HSA-451898
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: JAK1: P23458
Identifier: R-HSA-8983168
Species: Homo sapiens
Compartment: endosome
Primary external reference: UniProt: P23458
Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
JAK1 icon
Tyrosine-protein kinase JAK1