Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/145)
Date Identifier Pathway Reference
2020-02-25 R-HSA-9671555 Signaling by PDGFR in disease BibTex
2020-02-25 R-HSA-9674428 PDGFR mutants bind TKIs BibTex
2020-02-25 R-HSA-9674415 Drug resistance of PDGFR mutants BibTex
2020-02-25 R-HSA-9674396 Imatinib-resistant PDGFR mutants BibTex
2020-02-25 R-HSA-9674404 Sorafenib-resistant PDGFR mutants BibTex
2020-02-25 R-HSA-9674401 Sunitinib-resistant PDGFR mutants BibTex
2020-02-25 R-HSA-9674403 Regorafenib-resistant PDGFR mutants BibTex
2020-02-25 R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants BibTex
2020-02-25 R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins BibTex
2020-02-25 R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants BibTex
2020-02-25 R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB BibTex
2020-01-31 R-HSA-9675108 Nervous system development BibTex
2019-08-16 R-HSA-9031628 NGF-stimulated transcription BibTex
2019-08-16 R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination BibTex
2018-12-15 R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BibTex
Authored Reactions (15/1,003)
Date Identifier Reaction Reference
2020-02-25 R-HSA-9674430 PDGFR mutants bind type II TKIs BibTex
2020-02-25 R-HSA-9674427 PDGFR mutants bind type I TKIs BibTex
2020-02-25 R-HSA-9674397 Imatinib-resistant PDGFR mutants don't bind imatinib BibTex
2020-02-25 R-HSA-9674414 Sorafenib-resistant PDGFR mutants don't bind sorefenib BibTex
2020-02-25 R-HSA-9674398 D842V PDGFRA doesn't bind sunitinib BibTex
2020-02-25 R-HSA-9674408 Regorafenib-resistant PDGFR mutants don't bind regorafenib BibTex
2020-02-25 R-HSA-9674095 PDGFRs bind type II TKI BibTex
2020-02-25 R-HSA-9674015 Olaratumab binds PDGFRA BibTex
2020-02-25 R-HSA-9674093 PDGFRs bind type I TKI BibTex
2020-02-25 R-HSA-9672177 PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR BibTex
2020-02-25 R-HSA-9672172 PI3-kinase binds to mutant PDGFR receptor BibTex
2020-02-25 R-HSA-9672175 Autophosphorylation of PDGFR mutant dimers BibTex
2020-02-25 R-HSA-9672168 Ligand-independent dimerization of PDGFR mutants BibTex
2020-02-25 R-HSA-9672176 STAT binds to the mutant PDGFRA receptor BibTex
2020-02-25 R-HSA-9672164 GRB2:SOS1 complex binds to mutant PDGFR receptor BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) BibTex
Reviewed Reactions (12/12)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex