Reactome: A Curated Pathway Database

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate

Stable Identifier
R-HSA-73792
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
Locations in the PathwayBrowser
Summation

Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
GMP synthase activity of GMPS [cytosol] GMPS [cytosol] GMP synthase activity (0003921)
Orthologous Events
Cross References
Rhea