Reactome: A Curated Pathway Database

AIR + CO2 => CAIR

Stable Identifier
R-HSA-73806
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
Locations in the PathwayBrowser
Summation

The reversible carboxylation of 5'-phosphoribosyl-5-aminoimidazole (AIR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) is catalyzed by the phosphoribosylaminoimidazole carboxylase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol] PAICS octamer [cytosol] phosphoribosylaminoimidazole carboxylase activity (0004638)
Orthologous Events
Cross References
Rhea