5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

Stable Identifier
R-HSA-73814
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
Locations in the PathwayBrowser
Summation

The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoribosylamine-glycine ligase activity of GART [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea