Reactome: A Curated Pathway Database

5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

Stable Identifier
R-HSA-73814
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
Locations in the PathwayBrowser
Summation

The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylamine-glycine ligase activity of GART [cytosol] GART [cytosol] phosphoribosylamine-glycine ligase activity (0004637)
Orthologous Events
Cross References
Rhea