Reactome: A Curated Pathway Database

FAICAR => IMP + H2O

Stable Identifier
R-HSA-73797
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
Locations in the PathwayBrowser
Summation

The reversible synthesis of inosine 5'-monophosphate from 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) is catalyzed by the IMP cyclohydrolase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
IMP cyclohydrolase activity of ATIC dimer [cytosol] ATIC dimer [cytosol] IMP cyclohydrolase activity (0003937)
Orthologous Events
Cross References
Rhea