(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)

Stable Identifier
R-HSA-74241
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Literature References
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenosine deaminase activity of ADA [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea