Reactome: A Curated Pathway Database

FGAM + ATP => AIR + ADP + Pi

Stable Identifier
R-HSA-73810
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
Locations in the PathwayBrowser
Summation

The irreversible synthesis of cytosolic 5'-phosphoribosyl-5-aminoimidazole (AIR) from 5'-phosphoribosylformylglycinamidine (FGAM), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic and may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylformylglycinamidine cyclo-ligase activity of GART [cytosol] GART [cytosol] phosphoribosylformylglycinamidine cyclo-ligase activity (0004641)
Orthologous Events
Cross References
Rhea