Reactome: A Curated Pathway Database

Guanine + H2O => Xanthine + NH4+

Stable Identifier
R-HSA-74255
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanine deaminase activity of GDA dimer [cytosol] GDA dimer [cytosol] guanine deaminase activity (0008892)
Orthologous Events
Cross References
Rhea