Reactome: A Curated Pathway Database

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

Stable Identifier
R-HSA-73812
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
Locations in the PathwayBrowser
Summation

The irreversible transfer of an amino group from L-glutamine to 5'-phosphoribosylformylglycinamide (FGAR), forming 5'-phosphoribosylformylglycinamidine (FGAM) and glutamate, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by phosphoribosylformylglycinamidine synthetase. The human enzyme has been purified and characterized biochemically (Barnes et al. 1994). Fluoresence microscopy studies of cultured human cells have shown that the enzyme is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol] PFAS [cytosol] phosphoribosylformylglycinamidine synthase activity (0004642)
Orthologous Events
Cross References
Rhea