MAP2K1 phosphorylates MAPK3

Stable Identifier
R-HSA-109860
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol]
Physical Entity
Activity
This entity is regulated by
Orthologous Events