Reactome: A Curated Pathway Database

CAIR + Aspartate + ATP => SAICAR + ADP + Pi

Stable Identifier
R-HSA-73805
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
Locations in the PathwayBrowser
Summation

The conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) and aspartate to 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole succinocarboxamide synthetase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of PAICS octamer [cytosol] PAICS octamer [cytosol] phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (0004639)
Orthologous Events
Cross References
Rhea