Reactome | cul4a [nucleoplasm]

cul4a [nucleoplasm]

Stable Identifier

R-XTR-976006

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

CUL4A, Q08D74

Locations in the PathwayBrowser

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DNA Repair (Xenopus tropicalis)

- DNA Damage Bypass (Xenopus tropicalis)
  - Recognition of DNA damage by PCNA-containing replication complex (Xenopus tropicalis)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
- Nucleotide Excision Repair (Xenopus tropicalis)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
    - DNA Damage Recognition in GG-NER (Xenopus tropicalis)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - UV-DDB ubiquitinates XPC (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)
        
        UV-DDB:COP9 Signalosome [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
    - Dual Incision in GG-NER (Xenopus tropicalis)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Xenopus tropicalis)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Xenopus tropicalis)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
    - Formation of Incision Complex in GG-NER (Xenopus tropicalis)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - Recruitment of XPA and release of CAK (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        PAR-UV-DDB [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
    - Dual incision in TC-NER (Xenopus tropicalis)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)
        
        TC-NER incision complex [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
        
        TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
    - Formation of TC-NER Pre-Incision Complex (Xenopus tropicalis)
      - ERCC8 (CSA) binds stalled RNA Pol II (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
        
        TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        cul4a [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q08D74

Gene Names

cul4a

Reference Genes

BioGPS Gene:548647 cul4a

ENSEMBL:ENSXETG00000001957

Monarch:548647 cul4a

NCBI Gene:548647 cul4a

Reference Transcript

Other Identifiers

548647

GO:0006511

GO:0007507

GO:0016567

GO:0030163

GO:0031461

GO:0031625

GO:0033339

GO:0035118

GO:0036211

GO:0048856

GO:0071600

Participates

as a component of

Other forms of this molecule

cul4a [nucleoplasm]

Inferred From

CUL4 [nucleoplasm] (Homo sapiens)

CUL4A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_017946717.1, XP_012812359.1

Xenbase

XB-GENE-1014775

Ensembl

ENSXETP00000004170, ENSXETT00000004170, ENSXETG00000001957

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