Reactome | top3a [nucleoplasm]

top3a [nucleoplasm]

Stable Identifier

R-XTR-912452

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

TOP3A, F7A1S4

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - G2/M Checkpoints (Xenopus tropicalis)
    - G2/M DNA damage checkpoint (Xenopus tropicalis)
      - ATR phosphorylates TP53 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)

DNA Repair (Xenopus tropicalis)

- DNA Double-Strand Break Repair (Xenopus tropicalis)
  - Homology Directed Repair (Xenopus tropicalis)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
      - HDR through Homologous Recombination (HRR) (Xenopus tropicalis)
        
        Resolution of D-Loop Structures (Xenopus tropicalis)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Xenopus tropicalis)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
      - HDR through Single Strand Annealing (SSA) (Xenopus tropicalis)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
      - Processing of DNA double-strand break ends (Xenopus tropicalis)
        
        ATR phosphorylates RPA2 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - Regulation of TP53 Activity (Xenopus tropicalis)
        
        Regulation of TP53 Activity through Phosphorylation (Xenopus tropicalis)
        
        ATR phosphorylates TP53 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Xenopus tropicalis)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)
        
        top3a [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7A1S4

Gene Names

top3a

Reference Genes

ENSEMBL:ENSXETG00000005765

KEGG Gene (Xenopus tropicalis):100135734 top3a

Reference Transcript

RefSeq:XM_004918070.4 top3a

Other Identifiers

100135734

GO:0003677

GO:0003824

GO:0003916

GO:0003917

GO:0005694

GO:0006265

GO:0008270

GO:0016853

GO:0043226

GO:0046872

GO:0140097

Participates

as a component of

BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Xenopus tropicalis)

Inferred From

TOP3A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_004918127.2

Ensembl

ENSXETT00000012696, ENSXETP00000012696, ENSXETG00000005765

Xenbase

XB-GENE-1003600

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