Reactome | RPS19 [cytosol]

RPS19 [cytosol]

Stable Identifier

R-XTR-72343

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

F6VPX2

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)
- rRNA processing (Xenopus tropicalis)
  - rRNA processing in the nucleus and cytosol (Xenopus tropicalis)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Xenopus tropicalis)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPS19 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6VPX2

Reference Genes

BioGPS Gene:100379722

dbSNP Gene:100379722

ENSEMBL:ENSXETG00000025510

KEGG Gene (Xenopus tropicalis):100379722

Monarch:100379722

NCBI Gene:100379722

Reference Transcript

RefSeq:XM_002939126.4

Other Identifiers

100379722

AAMC01089119

ENSXETG00000025510

ENSXETP00000033057

ENSXETT00000033057

EntrezGene:100379722

EntrezGene:rps19

GO:0000028

GO:0002376

GO:0003674

GO:0003735

GO:0005198

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0022607

GO:0022618

GO:0022627

GO:0030154

GO:0030218

GO:0032991

GO:0034641

GO:0035284

GO:0042254

GO:0042541

GO:0042592

GO:0043009

GO:0043226

GO:0045088

GO:0045646

GO:0048821

GO:0048856

GO:0065003

GO:0072332

IPR001266

IPR018277

IPR036390

IPR038111

PF01090

rps19

rps19-201

SM01413

Str.1374.7.S1_at

UPI0001DE816C

XB-GENE-968799

XP_002939172

Participant Of

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

RPS19 [nucleoplasm]

Inferred From

RPS19 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002939172.2