Reactome | mbd3 [nucleoplasm]

mbd3 [nucleoplasm]

Stable Identifier

R-XTR-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

MBD3, Q6DK69

Locations in the PathwayBrowser

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Chromatin organization (Xenopus tropicalis)

- Chromatin modifying enzymes (Xenopus tropicalis)
  - HDACs deacetylate histones (Xenopus tropicalis)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)
      - HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase I Transcription (Xenopus tropicalis)
  - RNA Polymerase I Promoter Clearance (Xenopus tropicalis)
    - RNA Polymerase I Transcription Initiation (Xenopus tropicalis)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)
- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - Regulation of TP53 Activity (Xenopus tropicalis)
        
        Regulation of TP53 Activity through Acetylation (Xenopus tropicalis)
        
        MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)
        
        MTA2-NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Intracellular signaling by second messengers (Xenopus tropicalis)
  - PIP3 activates AKT signaling (Xenopus tropicalis)
    - PTEN Regulation (Xenopus tropicalis)
      - Regulation of PTEN gene transcription (Xenopus tropicalis)
        
        SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Xenopus tropicalis)
        
        SALL4:NuRD [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mbd3 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6DK69

Gene Names

mbd3

Reference Genes

BioGPS Gene:448748 mbd3

ENSEMBL:ENSXETG00000013593

KEGG Gene (Xenopus tropicalis):448748 mbd3

Monarch:448748 mbd3

NCBI Gene:448748 mbd3

Reference Transcript

RefSeq:NM_001006900.1 mbd3

Participates

as a component of

Other forms of this molecule

mbd3 [nucleoplasm]

mbd3 [nucleoplasm]

mbd3 [nucleoplasm]

Inferred From

MBD3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001006901.1

Xenbase

XB-GENE-491553

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