Reactome | PLK4 [cytosol]

PLK4 [cytosol]

Stable Identifier

R-XTR-380286

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

B3DL84

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Xenopus tropicalis)

- Cilium Assembly (Xenopus tropicalis)
  - Anchoring of the basal body to the plasma membrane (Xenopus tropicalis)
    - C2CD3 binds the mother centriole (Xenopus tropicalis)
      - mother centriole [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
      - mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)
      - basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
        
        basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
    - CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)
      - basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
        
        basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
    - The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        PLK4 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:B3DL84

Reference Genes

BioGPS Gene:100038180

ENSEMBL:ENSXETG00000022522

KEGG Gene (Xenopus tropicalis):100038180

Monarch:100038180

NCBI Gene:100038180

Reference Transcript

RefSeq:NM_001128656.1

Participates

as a component of

Inferred From

PLK4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001122128.1

Xenbase

XB-GENE-493608

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