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RBCK1 [cytosol]
Stable Identifier
R-SSC-976018
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
RBCK1, F1S7J3
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
Polyubiquitination of substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
Release of E3 from polyubiquitinated substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
TNFR1-induced proapoptotic signaling (Sus scrofa)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
RBCK1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1S7J3
Gene Names
RBCK1
Reference Genes
ENSEMBL:ENSSSCG00000007206.5
Other Identifiers
100519985
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0012501
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0036211
GO:0042742
GO:0042802
GO:0043065
GO:0043123
GO:0043130
GO:0043161
GO:0046872
GO:0050852
GO:0060546
GO:0071797
GO:0097039
GO:0098542
GO:0140096
GO:1901224
GO:2001238
Participates
as a component of
LUBAC [cytosol] (Sus scrofa)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
Inferred From
RBCK1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000125826
Ensembl
ENSSSCP00000007674
,
ENSSSCG00000007206
,
ENSSSCT00000007885
VGNC
98284
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