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ITCH [cytosol]
Stable Identifier
R-SSC-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
A0A287A7X1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional regulation by RUNX1 (Sus scrofa)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Sus scrofa)
ITCH polyubiquitinates TP73 (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Polyubiquitination of substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Release of E3 from polyubiquitinated substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Programmed Cell Death (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
ITCH polyubiquitinates MLKL at K50 (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
MLKL binds ITCH (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
Degradation of GLI1 by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Hedgehog 'on' state (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH binds GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ub-GLI is degraded by the proteasome (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Signaling by NOTCH (Sus scrofa)
Signaling by NOTCH1 (Sus scrofa)
Activated NOTCH1 Transmits Signal to the Nucleus (Sus scrofa)
ITCH binds DTX (Sus scrofa)
DTX:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ITCH ubiquitinates DTX (Sus scrofa)
DTX:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Ub-DTX:ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ERBB4 (Sus scrofa)
Downregulation of ERBB4 signaling (Sus scrofa)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Sus scrofa)
WWP1/ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
WWP1/ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Sus scrofa)
WWP1/ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Sus scrofa)
WWP1/ITCH [cytosol] (Sus scrofa)
ITCH [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287A7X1
Reference Genes
ENSEMBL:ENSSSCG00000007280.6
ENSEMBL:ENSSSCG00005004277.1
Other Identifiers
GO:0000209
GO:0002376
GO:0002669
GO:0002870
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005938
GO:0006511
GO:0006513
GO:0007155
GO:0012501
GO:0016020
GO:0016192
GO:0016567
GO:0016740
GO:0016874
GO:0023052
GO:0030163
GO:0031410
GO:0031623
GO:0032991
GO:0035519
GO:0035739
GO:0036211
GO:0043021
GO:0043066
GO:0043161
GO:0043226
GO:0043231
GO:0044389
GO:0045236
GO:0045732
GO:0046329
GO:0048856
GO:0050687
GO:0051865
GO:0061630
GO:0070534
GO:0070936
GO:0090085
GO:0098542
GO:0140096
GO:1990763
GO:2000562
GO:2000646
Ssc.20430.1.A1_at
Participates
as a member of
WWP1/ITCH [cytosol] (Sus scrofa)
as an input of
NUMB binds ITCH (Sus scrofa)
ITCH binds DTX (Sus scrofa)
MLKL binds ITCH (Sus scrofa)
as a component of
NUMB:ITCH [cytosol] (Sus scrofa)
Ub-DTX:ITCH [cytosol] (Sus scrofa)
DTX:ITCH [cytosol] (Sus scrofa)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Sus scrofa)
as an output of
ITCH polyubiquitinates MLKL at K50 (Sus scrofa)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
Other forms of this molecule
Ub-C871-ITCH [cytosol]
Inferred From
ITCH [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSSSCP00000039980
,
ENSSSCG00000007280
,
ENSSSCT00000036444
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