Reactome | UPF3A [cytosol]

UPF3A [cytosol]

Stable Identifier

R-SSC-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

UPF3A, A0A287B653

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        UPF3 [cytosol] (Sus scrofa)
        
        UPF3A [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B653

Gene Names

UPF3A

Reference Genes

ENSEMBL:ENSSSCG00000024679.4

Other Identifiers

100621841

GO:0000184

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0016071

GO:0035145

GO:0042162

GO:0043226

GO:0043231

GO:0045727

Ssc.6851.1.A1_at

Participates

as a component of

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)

as a member of

UPF3 [cytosol] (Sus scrofa)

Inferred From

UPF3AS-2 [cytosol] (Homo sapiens)

UPF3A [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000169062

Ensembl

ENSSSCT00000061733, ENSSSCG00000024679, ENSSSCP00000051568

VGNC

94719