Reactome | PIK3CA [cytosol]

PIK3CA [cytosol]

Stable Identifier

R-SSC-74787

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

PIK3CA, A0A5K1UB41

Locations in the PathwayBrowser

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Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - RET signaling (Sus scrofa)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Costimulation by the CD28 family (Sus scrofa)
    - CD28 co-stimulation (Sus scrofa)
      - CD28 dependent PI3K/Akt signaling (Sus scrofa)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K binds CD28 (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
    - PI3K binds ICOS (Sus scrofa)
      - ICOS:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Downstream TCR signaling (Sus scrofa)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - Recruitment of PI3K to plasma membrane (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - FLT3 Signaling (Sus scrofa)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - PIK3CA [cytosol] (Sus scrofa)
    - Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)
      - PIK3CA [cytosol] (Sus scrofa)
      - active FLT3:p-Y GRB10:PI3K [plasma membrane] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - 14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - Regulation of signaling by CBL (Sus scrofa)
        
        CBL ubiquitinates PI3K (Sus scrofa)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        K63polyUb-PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
      - PI3K associates with phosphorylated GAB2 (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Role of phospholipids in phagocytosis (Sus scrofa)
      - PI3K binds to p-6Y-SYK (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CA [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5K1UB41

Gene Names

PIK3CA

Reference Genes

ENSEMBL:ENSSSCG00000030413.4

Other Identifiers

100621789

GO:0000166

GO:0001889

GO:0001932

GO:0003012

GO:0003013

GO:0003824

GO:0005524

GO:0005737

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0005975

GO:0006006

GO:0006091

GO:0006629

GO:0007010

GO:0008286

GO:0010468

GO:0012501

GO:0014065

GO:0014704

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0023052

GO:0030027

GO:0030036

GO:0030295

GO:0030835

GO:0032869

GO:0035004

GO:0035005

GO:0035994

GO:0036092

GO:0036211

GO:0038084

GO:0040014

GO:0043457

GO:0043491

GO:0043524

GO:0043560

GO:0046854

GO:0046934

GO:0048009

GO:0048015

GO:0048856

GO:0051897

GO:0055119

GO:0060612

GO:0071333

GO:0071464

GO:0086003

GO:0097009

GO:0098772

GO:0110053

GO:0141068

GO:1905477

GO:2000270

GO:2000811

Participates

as an input of

as a component of

as a member of

PI3K-catalytic subunit [cytosol] (Sus scrofa)

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000121879

Ensembl

ENSSSCG00000030413, ENSSSCP00000052984, ENSSSCT00000039550

VGNC

91440

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