Reactome | PRKAG3 [cytosol]

PRKAG3 [cytosol]

Stable Identifier

R-SSC-381839

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

PRKAG3, F1SRX0

Locations in the PathwayBrowser

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Autophagy (Sus scrofa)

- Macroautophagy (Sus scrofa)
  - AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - Thr-180 of ULK1 is phosphorylated (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - ULK complex translocates to the ER (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates Beclin-1 (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - p-AMPK:AMP binds the ULK complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - TP53 Regulates Metabolic Genes (Sus scrofa)
        
        SESN1,2,3 bind AMPK (Sus scrofa)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)
        
        p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG3 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SRX0

Gene Names

PRKAG3

Reference Genes

ENSEMBL:ENSSSCG00000016200.6

Other Identifiers

397149

GO:0003012

GO:0003824

GO:0004679

GO:0005634

GO:0005737

GO:0005975

GO:0005978

GO:0006091

GO:0006096

GO:0014873

GO:0016208

GO:0016740

GO:0019887

GO:0019901

GO:0031588

GO:0031669

GO:0043226

GO:0055086

GO:0098772

GO:0140096

GO:1901135

Ssc.13820.1.A1_at

Participates

as a member of

AMPK gamma [cytosol] (Sus scrofa)

Other forms of this molecule

PRKAG3 [nucleoplasm]

Inferred From

PRKAG3 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000115592

Ensembl

ENSSSCT00000017641, ENSSSCG00000016200, ENSSSCP00000017163

VGNC

98221

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